- SYNTHESIS OF UBIQUINONE AND MENAQUINONE ANALOGUES BY OXIDATIVE DEMETHYLATION OF ALKENYLHYDROQUINONE ETHERS WITH ARGENTIC OXIDE OR CERIC AMMONIUM NITRATE IN THE PRESENCE OF 2,4,6-PYRIDINE-TRICARBOXYLIC ACID
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It was found that alkenylhydroquinone ethers demethylated with argentic oxide or ceric ammonium nitrate in the presence of 2,4,6-pyridinetricarboxylic acid as a catalyst and afforded ubiquinone-2, menaquinone-2 and their analogs in yields of 53 to 89 percent.The new approach to the synthesis of starting alkenylhydroquinone ethers as well as 2,4,6-pyridinetricarboxylic acid and its derivatives has been reported.
- Syper, L.,Kloc, K.,Mlochowski, J.
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- Preparation of key intermediates for the syntheses of coenzyme Q10 and derivatives by cross-metathesis reactions
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An alternative catalytic strategy for the preparation of benzylmethacrylate esters, key intermediates in the synthesis of coenzyme Q10 and derivatives, was reported. This strategy avoided undesirable stoichiometric reduction/oxidation processes by utilizi
- Nguyen, Trang,Mac, Hung,Pham, Phong
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- QUINONE BASED NITRIC OXIDE DONATING COMPOUNDS
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The present invention relates to nitric oxide donor compounds having a quinone based structure, to processes for their preparation and to their use in the treatment and/or prophylaxis of glaucoma and ocular hypertension.
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Page/Page column 41; 42
(2015/11/18)
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- QUINONE BASED NITRIC OXIDE DONATING COMPOUNDS FOR OPHTHALMIC USE
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The present invention relates to novel nitric oxide donor compounds for the use in the treatment and/or prophylaxis of hypertensive glaucoma, normotensive glaucoma and ocular hypertension.
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Page/Page column 47
(2014/05/24)
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- QUINONE BASED NITRIC OXIDE DONATING COMPOUNDS
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The present invention relates to nitric oxide donor compounds having a quinone based structure, to processes for their preparation and to their use in the treatment of pathological conditions where a deficit of NO plays an important role in their pathogenesis.
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Page/Page column 50-51
(2013/05/21)
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- Synthesis and characterization of mitoQ and idebenone analogues as mediators of oxygen consumption in mitochondria
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Analogues of mitoQ and idebenone were synthesized to define the structural elements that support oxygen consumption in the mitochondrial respiratory chain. Eight analogues were prepared and fully characterized, then evaluated for their ability to support oxygen consumption in the mitochondrial respiratory chain. While oxygen consumption was strongly inhibited by mitoQ analogues 2-4 in a chain length-dependent manner, modification of idebenone by replacement of the quinone methoxy groups by methyl groups (analogues 6-8) reduced, but did not eliminate, oxygen consumption. Idebenone analogues 6-8 also displayed significant cytoprotective properties toward cultured mammalian cells in which glutathione had been depleted by treatment with diethyl maleate.
- Duveau, Damien Y.,Arce, Pablo M.,Schoenfeld, Robert A.,Raghav, Nidhi,Cortopassi, Gino A.,Hecht, Sidney M.
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experimental part
p. 6429 - 6441
(2010/10/03)
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- MITOQUINONE DERIVATIVES USED AS MITOCHONDRIALLY TARGETED ANTIOXIDANTS
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This invention relates to pharmaceutically acceptable amphiphilic antioxidant compounds, compositions and dosage forms comprising said compounds, and methods and uses reliant on said compounds.The exemplified compounds are all mitoquinone derivatives, bei
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Page/Page column 52-53
(2010/02/11)
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- Thiazolidine compounds containing a quinone group, their preparation and their therapeutic uses
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Compounds of formula (I): STR1 (wherein: R1 is alkyl; R2 and R3 are each alkyl or alkoxy, or R2 and R3 together form an optionally substituted benzene ring and, when R2 and R3 together form said benzene ring, R1 is hydrogen, halogen or alkyl; R4 and R5 both represent hydrogen, or together represent a single carbon-carbon bond; W is a single bond or alkylene; and Z is a hydrogen atom or a cation) have valuable therapeutic and prophylactic activities, including anti-diabetic activities.
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- Thiazolidine compounds, their preparation and their therapeutic uses
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Compounds of formula (I): (in which: R1 is alkyl; R2 and R3 are each alkyl or alkoxy, or R2 and R3 together form an optionally substituted benzene ring, and, when R2 and R3 together form said benzene ring, R1 is hydrogen, halogen or alkyl; R4 and R5 are hydrogen, or R4 and R5 together represent a single carbon-carbon bond; Y1 and Y2 are each hydrogen, alkyl, acyl, or optionally substituted benzoyl, naphthoyl, pyridine-carbonyl or quinolinecarbonyl; W is a single bond or alkylene; and Z is hydrogen or a cation) have valuable therapeutic and prophylactic activities, including anti-diabetic activities.
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