cas 7197-01-5, 6-Chloro-3-methyl[1,2,4]triazolo[4,3-b]pyridazine

Articles about 7197-01-5Total 12 be found

ARYLACETAMIDE ANALOGS OF PIPERAZINE-[1,2,4]TRIAZOLO[4,3-B]PYRIDAZINES
Provided are compounds with the following structure: Formula (I), and methods of making and using same. The methods of using the compounds may be methods for treating or prophylaxis of a cryptosporidium infection.
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Paragraph 0092; 0095

(2021/12/31)

INHIBITORS OF LIN28 AND METHODS OF USE THEREOF
The present disclosure relates to compounds of formula (I) and compositions comprising the same. The disclosure further relates to methods of treating cancers.
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Page/Page column 52-53; 86

(2021/06/26)

TRIAZOLOPHTHALAZINE COMPOUNDS, USE AS ANTI-HUMAN IMMUNODEFICIENCY VIRUS INHIBITORS OF HIV VIF-DEPENDENT DEGRADATION OF APOBEC3
The present disclosure is concerned with triazolophthalazine compounds that are capable of inhibiting infection by the Human Immunodeficiency Virus (HIV) by inhibiting HIV Vif-dependent degradation of the APOBEC3 innate immune system. The present disclosu
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Paragraph 00330; 00336

(2019/07/17)

Synthesis and bioevaluation of 6-chloropyridazin-3-yl hydrazones and 6-chloro-3-substituted-[1,2,4]triazolo[4,3-b]pyridazines as cytotoxic agents
An efficient synthesis of a series of 6-chloro-3-substituted-[1,2,4]triazolo[4,3-b]pyridazines is described via intramolecular oxidative cyclization of various 6-chloropyridazin-3-yl hydrazones with iodobenzene diacetate. The structures of the newly synth
Mamta,Aggarwal, Ranjana,Sadana, Rachna,Ilag, Jeziel,Sumran, Garima
p. 288 - 295
(2019/02/12)

TRIAZOLO COMPOUNDS
The present invention relates to compounds of formula (I) and its use for the treatment of neurological disorders.
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Page/Page column 75; 76

(2014/05/24)

Synthesis and antiproliferative activity of 2-(([1,2,4]triazolo[4,3-b]- pyridazin-6-yloxy)methyl)-2,4-dimethyl-3,4-dihydro-2Hbenzo[b][1,4]oxazine derivatives
A small library of [1,2,4]triazolo[4,3-b]pyridazin-6-yloxy derivatives 14-17 of N-benzyl-N-(2-((4-amidinophenoxy)methyl)-2,4-dimethyl-3,4-dihydro-2H- benzo[b][1,4]oxazin-7-yl)-oxalic acid monoamides 1 was prepared by replacement of benzamidine with a [1,2
Ilic, Milos,Ilas, Janez,Liekens, Sandra,Matyus, Peter,Kikelj, Danijel
scheme or table
p. 298 - 311
(2011/12/15)

Nucleophilic substitution reactions, molecular aggregation, structure and lipophilicity of 6-chloro-3-chloromethyl-1,2,4-triazolo[4,3-b]pyridazine
The synthesis of 6-chloro-3-chloromethyl-1,2,4-triazolo[4,3-b] pyridazine and its vicarious nucleophilic substitution products are described and characterized by spectroscopic methods and X-ray diffraction. The lipophilicities of the title compound, its a
Katrusiak, Anna,Katrusiak, Andrzej
experimental part
p. 308 - 318
(2010/10/03)

AMINOPIPERIDINES AS DIPEPTIDYL PEPTIDASE-IV INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES
The present invention is directed to novel substituted aminopiperidines which are inhibitors of the dipeptidyl peptidase-IV enzyme ("DPP-IV inhibitors") and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly Type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.
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Page/Page column 32; 41

(2010/10/20)

4-Acylhydrazinomethylene-2-phenyloxazol-5(4H)-ones as acylating agents: Synthesis of salicylanilides and 1,2,4-triazolo[4,3-b] pyridazines
A simple and general method for the acylation of an amino or hydrazino group by the application of hydrazides has been developed. It starts from hydrazides (2), which are converted with 4-ethoxymethylene-2-phenyl-oxazol-5(4H)-one (1) to the corresponding 4-acylhydrazinomethylene-2-phenyloxazol-5(4H)-ones (3). The latter react with nitrogen-containing nucleophiles in 1,4-dioxane in the presence of triethylamine or zirconium(IV) chloride to give the corresponding amides (7) or mixtures of hydrazides (12) and 1,2,4-triazolo[4,3-b]pyridazines (11). Upon prolonged heating, compounds (11) are the main products.
Po?gan, Franc,Polanc, Slovenko,Ko?evar, Marijan
p. 1011 - 1019
(2007/10/03)

Synthesis and Reactivity of some 1,2,4-Triazolopyridazine Derivatives
The triazolopyridazine derivatives were obtained in the reaction of 3-chloro-6-hydrazinopyridazine with acetic acid and ethyl chloroformate.Acting on 6-chloro-3-methyl-1,2,4-triazolopyridazine with phosphorus pentachloride, a methyl group in position 3 has unexpectedly been exchanged by chlorine.The mechanism of fusing the triazole ring to the pyridazine system has been studied by the reaction of 3-chloro-6-hydrazinopyridazine with formaldehyde, acetaldehyde, and treatment the resulting Schiff bases by bromine in acetic acid with sodium acetate added.Key words: 1,2,4-Triazolopyridazines, nucleophilic substitution, cyclization mechanism
Baloniak, S.,Katrusiak, A.
p. 683 - 692
(2007/10/02)

Reactions of 3-Chloro-6-hydrazinopyridazine with Michael-retro-Michael Reagents
Although pyrazole formation results from treatment of 3-chloro-6-hydrazinopyridazine (2) with both ethoxymethylenemalononitrile and ethyl (ethoxymethylene)cyanoacetate, 6-chlorotriazolopyridazine (5) was produced (75percent yield) when 2 was treated with diethyl ethoxymethylenemalonate.Treatment of 2 with diethyl acetylmalonate (8) gave both 6-chloro-3-methyltriazolopyridazine (10) and 5-hydroxy-3-methyl-1-(6-chloro-3-pyridazinyl)-1H-pyrazole-4-carboxylic acid ethyl ester (12).Pyrazole 12 was initially isolated as a salt of triazolopyridazine 10.
Sunder, Shyam,Peet, Norton P.
p. 1527 - 1529
(2007/10/02)