- Evaluation of lipase from Candida rugosa in the resolution of endo- (±)- 1,8,9,10,11,11-hexachloropentacyclo- [6.2.1.13,6.02,7.05,9]dodecan-4-alcohol
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endo-(±)-1,8,9,10,11,11- Hexachloropentacyclo[6.2.1.13,6.02,7.05,9)]dodecan-4-ol (±)-7 and exo-(±)1,8,9,10,11,11- hexachloropentacyclo[6.2.1.13,6,02,7.05,9]dodecan-4-ol (±)-4 have been prepared and the enantiomeric enrichment capacity of the lipase from Candida rugosa in the transesterification with vinyl acetate of these compounds was evaluated. It was verified that the lipase recognize only the alcohol (±)-7, producing endo-(+)- 1,8,9,10,11,11- hexachloropentacyclo[6.2.1.13,6.02,7.05,9]dodecan-4-yl acetate (+)- 8 with ee >95% and conversion of 44% as the only product.
- Costa, Valentim E. U.,Alifantes, Joao,Martins, Jose E. D.
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