- NOVEL HYDROXYBUTYRIC ACID ESTER
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PROBLEM TO BE SOLVED: To provide a novel 3HB ester that exhibits a cell activation effect in place of 3HB. SOLUTION: The present invention provides a novel hydroxybutyric acid ester represented by the following chemical formula, where n=8 (3HB stearoyl es
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Paragraph 0018
(2019/12/11)
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- HUMAN NORMAL CELL ACTIVATOR
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PROBLEM TO BE SOLVED: To provide a human normal cell activator. SOLUTION: The present invention provides a human normal cell activator containing at least one selected from the following 3-hydroxy butyric acid alkyl esters, where R is one selected from li
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Paragraph 0036
(2019/12/12)
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- New (2→3) bond type sialo-sugar chains
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PROBLEM TO BE SOLVED: To provide novel sialo-sugar chain, method for producing it, and production apparatus for it.SOLUTION: By reacting a sugar of which hydroxyl group at the reducing end is substituted with a reactive group, hereinafter referred to as a
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Paragraph 0297-0306
(2018/06/30)
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- Synthesis of structural analogues of hexadecylphosphocholine and their antineoplastic, antimicrobial and amoebicidal activity
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Twelve derivatives of hexadecylphosphocholine (miltefosine) were synthesized to determine how the position and length of the alkyl chain within the molecule influence their biological activities. The prepared alkylphosphocholines have the same molecular formula as miltefosine. Activity of the compounds was studied against a spectrum of tumour cells, two species of protozoans, bacteria and yeast. Antitumour efficacy of some alkylphosphocholines measured up on MCF-7, A2780, HUT-78 and THP-1 cell lines was higher than that of miltefosine. The compounds showed antiprotozoal activity against Acanthamoeba lugdunensis and Acanthamoeba quina. Some of them also possess fungicidal activity against Candida albicans equal to miltefosine. No antibacterial activity was observed against Staphylococcus aureus and Escherichia coli. A difference in position of a long hydrocarbon chain within the structure with maximum efficacy was observed for antitumour, antiprotozoal and antifungal activity.
- Timko, Luká?,Fischer-Fodor, Eva,Garajová, Mária,Mrva, Martin,Chereches, Gabriela,Ondriska, Franti?ek,Bukovsky, Marián,Luká?, Milo?,Karlovská, Janka,Kubincová, Janka,Devínsky, Ferdinand
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p. 263 - 273
(2015/05/26)
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- PROCESS FOR PRODUCING NOVEL SIALO-SUGAR CHAIN
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The present invention provides a novel sialo-sugar chain, a process for producing the sialo-sugar chain, and a device for producing the sialo-sugar chain. A sialo-sugar chain can be easily and efficiently mass-produced by reacting a sugar wherein a hydrox
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Paragraph 0157; 0158; 0159; 0160
(2014/08/06)
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- Rapid configuration analysis of the solenopsins
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A protocol for rapid access to the relative and absolute configurations of the solenopsins, the venom alkaloids of fire ants (Solenopsis spp.), was developed based on chiral capillary gas chromatography. The synthesis of racemic mixtures of 2-methyl-6-alkylpiperidines and the isolation of natural (2R,6R)- and (2R,6S)-2-methyl-6-undecylpiperidines allowed for the standardization of the chromatographic method. Application of this protocol revealed the previously unknown natural occurrence of four stereoisomers of 2-methyl-6-undecylpiperidine in venom samples from workers and gynes of Solenopsis saevissima.
- Pianaro, Adriana,Fox, Eduardo G.P.,Bueno, Odair C.,Marsaioli, Anita J.
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experimental part
p. 635 - 642
(2012/09/22)
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- Synthesis of all the six components of the female-produced contact sex pheromone of the German cockroach, Blattella germanica (L.)
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All of the following six components of the female sex pheromone of the German cockroach, Blattella germanica (L.) were synthesized: (3S,11S)-3,11-dimethyl-2-nonacosanone (1), its 29-hydroxy derivative 2, its 29-oxo derivative 3, (3S,11S)-3,11-dimethyl-2-heptacosanone (4), its 27-hydroxy derivative 5, and its 27-oxo derivative 6. Both the enantiomers of citronellal were employed as the chiral sources and Wacker oxidation was employed for the introduction of the carbonyl group at C-2.
- Mori, Kenji
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p. 4060 - 4071
(2008/09/20)
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- Solvent-free and selective tosylation of alcohols and phenols with p-toluenesulfonyl chloride by heteropolyacids as highly efficient catalysts
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Tosylation of some alcohols and phenols has been directly carried out with p-toluenesulfonyl chloride using heterodoxy acids (H3PW 12O40, H3PMo12O40, A 3PW12O40, and AlPMo12O40) as catalysts in the absence of solvent. We found that heteropoly acids AlPW12O40 and AlPMo 12O40 were effective catalysts for the tosylation of alcohols and phenols. In the case of aliphatic alcohols, secondary alcohols undergo tosylation chemoselectively in the presence of primary hydroxyl groups. This new method consistently has the advantage of excellent yields and short reaction time.
- Fazaeli, Razieh,Tangestaninejad, Shahram,Aliyan, Hamid
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p. 812 - 818
(2007/10/03)
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- Montmorillonite clay catalyzed tosylation of alcohols and selective monotosylation of diols with p-toluenesulfonic acid: An enviro-economic route
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An enviro-economic route for tosylation of alcohols and selective monotosylation of diols in good yield directly using p-toluenesulfonic acid together with metal-exchanged montmorillonite instead of p-toluenesulfonyl chloride or p-toluenesulfonic anhydrid
- Choudary, Boyapati M.,Chowdari, Naidu S.,Kantam, Mannepalli L.
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p. 7291 - 7298
(2007/10/03)
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