- Modulators of the human CCR5 receptor. Part 1: Discovery and initial SAR of 1-(3,3-diphenylpropyl)-piperidinyl amides and ureas
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Investigation of weak screening hits led to the identification of N-alkyl-N-[1-(3,3-diphenylpropyl)piperidin-4-yl]-2-phenylacetamides and N-alkyl-N-[1-(3,3-diphenylpropyl)piperidin-4-yl]-N′-benzylureas as potent, selective ligands for the human CCR5 chemokine receptor. Investigation of weak screening hits led to the identification of N-alkyl-N-[1-(3,3-diphenylpropyl) piperidin-4-yl]-2-phenylacetamides and N-alkyl-N-[1-(3,3-diphenylpropyl) piperidin-4-yl]-N′-benzylureas as potent, selective ligands for the human CCR5 chemokine receptor.
- Burrows, Jeremy N.,Cumming, John G.,Fillery, Shaun M.,Hamlin, Gordon A.,Hudson, Julian A.,Jackson, Ruth J.,McLaughlin, Sharon,Shaw, John S.
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- Pharmaceutically active piperidine derivatives, in particular as modulators of chemokine receptor activity
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Compounds of formula (I), compositions comprising them, processes for preparing them and their use in medical therapy (for example modulating CCR5 receptor activity in a warm blooded animal).
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(2010/11/30)
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