- 5-METHYL-6-PHENYL-4,5-DIHYDRO-2H-PYRIDAZIN-3-ONE DERIVATIVE
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The present invention provides an agent for treating malignant tumor, comprising a compound of formula (1): wherein R1 to R4 are hydrogen atom, halogen, or etc., Y is optionally-substituted alkylene group or etc.
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Paragraph 0141
(2017/09/15)
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- Mild synthesis of asymmetric 2′-carboxyethyl-substituted fluoresceins
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(Chemical Equation Presented) Asymmetric fluoresceins bearing a carboxyethyl group in the chromophoric portion of the dyes were prepared by a reaction of substituted phthalic anhydride with a carboxyethyl substituted resorcinol analogue followed by a condensation with a second resorcinol analogue. In order to avoid an accumulation of symmetric side products, the second step was performed in two substeps: acid-catalyzed formation of a triphenylmethyl intermediate followed by base-catalyzed cyclization which furnished the desired dyes.
- Lukhtanov, Eugeny A.,Vorobiev, Alexei V.
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p. 2424 - 2427
(2008/09/19)
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- Total synthesis of topopyrones B and D
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(Chemical Equation Presented) We describe a straightforward synthesis of topopyrones B and D, which are potent and selective inhibitors of topoisomerase I. The chemistry should be suitable for additional structure-activity relationship (SAR) work.
- Tan, Jason Samuel,Ciufolini, Marco A.
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p. 4771 - 4774
(2007/10/03)
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- 1,2-benzisoxazoloxyacetic acids and related compounds
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Novel 1,2-benzisoxazoloxyacetic acids and related compounds, methods for preparing same and methods of treatment by administering compositions containing such a compound are described. These compounds are useful as diuretic, uricosuric and antihypertensive agents.
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- Substituted 5,6-dihydrofuro[3,2-f]-1,2-benzisoxazole-6-carboxylic acids: High-ceiling diuretics with uricosuric activity
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A series of substituted 5,6-dihydrofuro[3,2-f]-1,2-benzisoxazoles was prepared and evaluated for their saluretic and uricosuric properties. Pharmacological evaluation of the title compounds was carried out in mice, rats, dogs, and monkeys. The diuretic/sa
- Plattner,Fung,Parks,et al.
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p. 1016 - 1026
(2007/10/02)
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- Benzisoxazole carboxylic acids
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Described are compounds of the formula STR1 wherein X is hydrogen, loweralkyl, halo, loweralkoxy or trifluoromethyl, and Z is hydrogen, loweralkyl, halo, hydroxy or alkoxy, or compounds of the formula STR2 wherein X' and Y' may be the same or different an
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- Benzisoxazole carboxylic acids
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Described are compounds of the formula STR1 wherein X is hydrogen, loweralkyl, halo, loweralkoxy or trifluoromethyl, and Z is hydrogen, loweralkyl, halo, hydroxy or alkoxy, or compounds of the formula STR2 wherein X' and Y' may be the same or different an
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