Deoxyribonucleic acid modification by mutagenic 3-amino-1-methyl-5H-pyrido[4,3-b]indole: the chemical events.
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Hashimoto,Shudo,Okamoto
p. 4300 - 4308
(2007/10/02)
Modification of DNA with Potent Mutacarcinogenic 2-Amino-6-methyldipyridoimidazole Isolated from a Glutamic Acid Pyrolysate: Structure of the Modified Nucleic Acid Base and Initial Chemical Event Caused by the Mutagen
2-Amino-6-methyldipyridoimidazole (Glu-P-1), a potent mutacarcinogen isolated from a glutamic acid pyrolysate, reacted with DNA in vitro and in vivo.The structure of the modified nucleic acid base was determined as 2-(8-guanylylamino)-6-met