- Fragmentation behavior of DOTA complexes under different activation conditions
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We have investigated the fragmentation behavior of a number of DOTA-metal complexes under collision-induced dissociation, infrared-multiphoton dissociation and higher-energy collisional dissociation activation conditions. Both, positive and negative ion mode electrospray ionization was applied. The results show that characteristic fragmentations were obtained for the metal-complexes under the investigated conditions. All elemental compositions of fragment ions have been unambiguously identified by high resolution-accurate mass measurements. Certain trends, for instance eliminations of carbon dioxide, alkyl and amine residues, were observed that coincide with the size of the metal and its location within the periodic table. Additionally, lanthanide, aluminium and indium species with even oxidation state or containing a radical have been detected. To further investigate the observed water capture during activation, deuterium labeling experiments have also been carried out. Copyright
- Beck,Trog,Knizia,Linscheid
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- Photoresponsive host-guest chemistry and relaxation time of fluorinated cyclodextrin and T1=T* 2 arylazopyrazole-functionalized DOTA metal complexes
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Light-responsive modulation of the longitudinal (T1) and transversal T *2) relaxation times of a fluorinated cyclodextrin has been achieved by host-guest complexation with arylazopyrazole-modified metal complexes in aqueous solution. This supramolecular concept can potentially be applied to the development of contrast agents for19F magnetic resonance imaging (MRI).
- Simke, Julian,B?ckermann, Till,Bergander, Klaus,Klabunde, Sina,Hansen, Michael Ryan,Ravoo, Bart Jan
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supporting information
p. 2186 - 2191
(2021/03/24)
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- Preparation method for 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid
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The invention relates to a preparation method for 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid. Specifically, the method uses a recrystallization method to obtain a high-purity compound represented by a formula I shown in the description, and further, meglumine and Gd2O3 are complexed with the compound represented by the formula I to obtain the gadoteric acid meglumine. The method disclosed by the invention is simple to operate, has low costs, and is green, environmentally friendly and suitable for large-scale production.
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Paragraph 0077-0079; 0080-0082
(2018/11/03)
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- Graphene Oxide Cellular Delivery of Hydrophilic Small Molecules
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Unmodified graphene oxide conjugated with hydrophilic small molecules for cellular delivery.
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Paragraph 0083; 0084; 0085
(2017/04/04)
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- Process for preparing contrast agent for magnetic resonance imaging
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The present invention relates to a method for manufacturing a contrast agent for magnetic resonance imaging (MRI) and, more specifically, to a method for manufacturing a contrast agent for magnetic resonance imaging (MRI), having improved stability by minimizing side effects by removing an unreacted substance generated in a manufacturing process. The manufacturing method comprises the following steps: forming a complex-containing aqueous solution by reacting lantanide and macrocyclic chelate; exchanging ions by using one or more resin among cation exchange resin, chelate resin, and anion exchange resin for removing free lantanide and unreacted macrocyclic chelate from the complex-containing aqueous solution; controlling pH of the complex aqueous solution into a neutral range; and removing germs in the complex aqueous solution.
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Paragraph 0041
(2017/04/03)
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- MAGfect: A novel liposome formulation for MRI labelling and visualization of cells
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Cellular entry of imaging probes, such as contrast agents for magnetic resonance imaging (MRI), is a key requirement for many molecular imaging studies, particularly imaging intracellular events and cell tracking. Here, we describe the successful development and in vitro analysis of MAGfect, a novel liposome formulation containing a lipidic gadolinium contrast agent for MRI, Gd-DOTA-Chol 1, designed to enter and label cells. Liposome formulation and cell incubation time were optimised for maximum cellular uptake of the imaging probe in a variety of cell lines. MRI analysis of cells incubated with MAGfect showed them to be highly MRI active. This formulation was examined further for cytotoxicity, cell viability and mechanism of cell labelling. One of the key advantages of using MAGfect as a labelling vehicle arises from its potential for additional functions, such as concomitant drug or gene delivery and fluorescent labelling. The gadolinium liposome was found to be an effective vehicle for transport of plasmid DNA (pDNA) into cells and expression levels were comparable to the commercial transfection agent Trojene. The Royal Society of Chemistry 2006.
- Oliver, Morag,Ahmad, Ayesha,Kamaly, Nazila,Perouzel, Eric,Caussin, Annabelle,Keller, Michael,Herlihy, Amy,Bell, Jimmy,Miller, Andrew D.,Jorgensen, Michael R.
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p. 3489 - 3497
(2008/09/17)
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