- PROCESS FOR PREPARING ε- EPSILON-CAPROLACTONE AND 1,6- HEXANEDIOL
-
The invention relates to processes for preparing 1,6-hexanediol and very pure ε-caprolactone from a dicarboxylic acid solution (DCS), comprising the steps of (a) esterification of the DCS with alcohols, (b) partial catalytic hydrogenation of the esters, (c) distillative removal of 1,6- hexanediol and low boilers as the top product, and (d) cyclization of the 6-hydroxycaproic ester present in the bottoms fraction in the presence of a higher-boiling alcohol than caprolactone.
- -
-
Page/Page column 19-21
(2012/04/10)
-
- Regioselective and stereoselective cyclizations of chloropolyols in water: Rapid synthesis of hydroxytetrahydrofurans
-
A concise, stereoselective synthesis of functionalized tetrahydrofuranols has been developed that involves heating readily available chloropolyols in water. These reactions are operationally straightforward and chemoselective for the formation of tetrahydrofurans, obviating the need for complicated protecting group strategies. The efficiency of this process is demonstrated in a short asymmetric synthesis of the natural product (+)-goniothalesdiol.
- Kang, Baldip,Chang, Stanley,Decker, Shannon,Britton, Robert
-
supporting information; body text
p. 1716 - 1719
(2010/09/05)
-