- COMPOUNDS FOR THE TREATMENT AND PREVENTION OF INFLUENZA
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A compound of formula (I) as well as pharmaceutically acceptable salt thereof, wherein R1 to R4 and Ar are as defined in description and in claims, can be used as a medicament.
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- COMPOUNDS FOR THE TREATMENT AND PREVENTION OF INFLUENZA
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A compound of formula (I) as well as pharmaceutically acceptable salt thereof, wherein R1 to R4 and Ar are as defined in description and in claims, can be used as a medicament.
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- COMPOUNDS FOR THE TREATMENT AND PREVENTION OF INFLUENZA
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A compound of formula (I) as well as pharmaceutically acceptable salt thereof, wherein R1 to R4 and Ar are as defined in description and in claims, can be used as a medicament.
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- Synthesis of 3H-labeled 2-hydroxy-N-[(1,3,3-trimethyl-[4,5,6-3H]cyclohexyl)methyl]-5-azidobenzamide, a photoaffinity analog of an influenza fusion inhibitor
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Synthesis of 3H-labeled 2-hydroxy-N-[(1,3,3-trimethyl-[4,5,6-3H]cyclohexyl)methyli]-5-azidobenzamide, a photoaffinity analog of an influenza fusion inhibitor, is reported. Tritiation of a mixture of N-(t-butoxycarbonyl)-1,3,3-trimethylcyclohex-4 (or 5)-enylmethylamine via T2 and Pd/C, followed by coupling of the deprotected tritiated amine with acetyl 5-azidosalicylic acid chloride yielded the penultimate product. Subsequent deprotection and normal phase HPLC purification yielded the target compound with a radiochemical purity > 99% and a specific activity of 63 Ci/mmol.
- Dischino, Douglas D.,Cianci, Christopher,Krystal, Mark,Meanwell, Nicholas A.,Morimoto, Hiromi,Pearce, Bradley C.,Williams, Philip,Yu, Kuo-Long
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p. 965 - 974
(2007/10/03)
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- STEREOCHIMIE-LII. CONTROLE ORBITALAIRE DE LA STEREOCHIMIE DES REACTIONS-III EFFETS DES GROUPES β-FLUORO ET β-CYANO SUR LA STEREOCHIMIE ET LA CINETIQUE DE LA REDUCTION DE CYCLOHEXANONES PAR LE TRITERTIOBUTOXYALUMINOHYDRURE DE LITHIUM
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The respective influences of β-fluoro and β-cyano groups on the reduction of ketones by Li(t-BuO)3AlH on the stereoselectivities of the reduction with and without added cryptands, and with and without added alkyl fluoride and nitrile, were compared with ab initio calculations using the frontier orbitals of analogous carbonyl compounds to give energy values
- Agami, C.,Kazakos, A.,Levisalles, J.,Sevin, A.
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p. 2977 - 2981
(2007/10/02)
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