- Oxidative and enantioselective cross-coupling of aldehydes and nitromethane catalyzed by diphenylprolinol silyl ether
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Synthetically important β-substituted γ-nitro aldehydes have been synthesized with excellent enantioselectivity by the cross-coupling reaction of β-aryl substituted aldehydes or Y γ-unsaturated aldehydes and nitromethane using 2,3-dichloro-5,6-dicyanoquinone (DDQ) and diphenylprolinol silyl ether as an oxidant and catalyst, respectively (see scheme; TMS=trimethylsilyl).
- Hayashi, Yujiro,Itoh, Takahiko,Ishikawa, Hayato
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supporting information; experimental part
p. 3920 - 3924
(2011/05/15)
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- Multi-catalysis cascade reactions based on the methoxycarbonylketene platform: Diversity-oriented synthesis of functionalized non-symmetrical malonates for agrochemicals and pharmaceuticals
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In this paper we describe new multi-catalysis cascade (MCC) reactions for the one-pot synthesis of highly functionalized non-symmetrical malonates. These metal-free reactions are either five-step (olefination/hydrogenation/alkylation/ ketenization/esterif
- Ramachary, Dhevalapally B.,Venkaiah, Chintalapudi,Reddy, Y. Vijayendar,Kishor, Mamillapalli
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supporting information; scheme or table
p. 2053 - 2062
(2009/09/05)
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- Lewis base-promoted hydrosilylation of cyclic malonates: Synthesis of β-substituted aldehydes and γ-substituted amines
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The Lewis base-promoted hydrosilylation of cyclic malonates provides a convenient synthesis of β-substituted aldehydes. No over-reduction to the primary alcohol is observed as the aldehyde functionality is protected until a subsequent hydrolysis step. The
- Frost, Christopher G.,Hartley, Benjamin C.
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supporting information; experimental part
p. 3599 - 3602
(2009/09/05)
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- A novel and green protocol for two-carbon homologation: A direct amino acid/K2CO3-catalyzed four-component reaction of aldehydes, active methylenes, Hantzsch esters and alkyl halides
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A novel and green approach for the two-carbon homologation of aldehydes using amino acid catalysis has been developed and further extended to the generation of pharmaceutically active cyano-esters via four-component reactions in one-pot.
- Ramachary, Dhevalapally B.,Kishor,Ramakumar
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p. 651 - 656
(2007/10/03)
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- Palladium(0)-Catalyzed Substitution of Allylic Substrates in an Aqueous-Organic Medium
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A palladium(0)-water soluble catalyst prepared in situ from palladium acetate and the sulfonated triphenyl phosphine P(C6H4-m-SO3Na)3 (or tppts) is an efficient catalyst for allylic substitution with various carbon and heteronucleophiles in an aqueous-organic medium, allowing a very easy separation of the product(s) and the recycling of the catalyst.
- Blart, Errol,Genet, Jean Pierre,Safi, Mohamed,Savignac, Monique,Sinou, Denis
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p. 505 - 514
(2007/10/02)
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- PALLADIUM CATALYZED C-ALLYLATION OF HIGHLY ACIDIC CARBO AND HETEROCYCLIC β-DICARBONYL COMPOUNDS
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Highly acidic carbo and heterocyclic β-dicarbonyl compounds such as barbituric acid, 3,5-dimethyl-2H-1,2,6-thiadiazine 1,1-dioxide, cyclohexane-1,3-dione, tetronic acids, Meldrum acid and 1,2-diphenylpyrazolidine-3,5-dione are efficiently C-allylated with primary and secondary allylating agents under palladium catalysis.
- Prat, M.,Moreno-Manas, M.,Ribas, J.
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p. 7205 - 7212
(2007/10/02)
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- Borohydride reduction of substituted isopropylidene methylenemalonates
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Knoevenagel-type products derived from Meldrum's Acid are readily reduced by sodium borohydride to give monosubstituted isopropylidene malonates in high yield.
- Wright, Allen D.,Haslego, Mark L.,Smith, Francis X.
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p. 2325 - 2326
(2007/10/09)
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