- Preparation method of aryl ketone compound
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The invention provides a preparation method of an aryl ketone compound, and belongs to the technical field of compound synthesis. The method comprises the following steps: under the action of a silver catalyst and water, carrying out reaction on aryl alkyne with a structure as shown in a formula 1 in a solvent at 60-120 DEG C for 12-48 hours, and separating and purifying a product after the reaction is finished, so as to obtain the single aryl ketone compound with a structure as shown in a formula I, the raw materials are easy to obtain, the experimental operation is simple, the yield of the prepared single aryl ketone compound is good, and gram-scale experiments can be carried out.
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Paragraph 0041-0049; 0061-0065; 0067
(2022/04/16)
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- Chiral Dibenzopentalene-Based Conjugated Nanohoops through Stereoselective Synthesis
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Conjugated nanohoops allow to investigate the effect of radial conjugation and bending on the involved π-systems. They can possess unexpected optoelectronic properties and their radially oriented π-system makes them attractive for host–guest chemistry. Be
- Hermann, Mathias,Wassy, Daniel,Kohn, Julia,Seitz, Philipp,Betschart, Martin U.,Grimme, Stefan,Esser, Birgit
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supporting information
p. 10680 - 10689
(2021/04/02)
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- Iron-Catalyzed C-C Single-Bond Cleavage of Alcohols
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An iron-catalyzed deconstruction/hydrogenation reaction of alcohols through C-C bond cleavage is developed through photocatalysis, to produce ketones or aldehydes as the products. Tertiary, secondary, and primary alcohols bearing a wide range of substituents are suitable substrates. Complex natural alcohols can also perform the transformation selectively. A investigation of the mechanism reveals a procedure that involves chlorine radical improved O-H homolysis, with the assistance of 2,4,6-collidine.
- Liu, Wei,Wu, Qiang,Wang, Miao,Huang, Yahao,Hu, Peng
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supporting information
p. 8413 - 8418
(2021/11/01)
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- NOVEL COMPOUND AND SEMICONDUCTOR MATERIAL CONTAINING THE SAME
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PROBLEM TO BE SOLVED: To provide a novel compound exhibiting n type semiconductor property with both of stability in air and solvent solubility, and a semiconductor element exhibiting stability in air and n type semiconductor property by using the compoun
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Paragraph 0071-0074
(2020/01/23)
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- Application of diphenylamino biphenyl carbonyl compounds to photocuring formula system
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The invention relates to the technical field of novel material organic chemicals, in particular to a diphenylamino biphenyl carbonyl compound shown as a formula (I), a purpose of the compound as a radiation curing photoinitiator, and application purposes
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Paragraph 0020-0022; 0024-0026
(2020/03/28)
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- Acyl hydrazides as acyl donors for the synthesis of diaryl and aryl alkyl ketones
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In this communication we describe a novel strategy for the formation of valuable diaryl and aryl alkyl ketones from acyl hydrazides. A wide variety of ketones are prepared and the mild reaction conditions allow for the use of a range of functionalities, especially in the synthesis of diaryl ketones.
- Akhbar, Ahmed R.,Chudasama, Vijay,Fitzmaurice, Richard J.,Powell, Lyn,Caddick, Stephen
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supporting information
p. 743 - 746
(2014/01/06)
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- Synthesis and methemoglobinemia-inducing properties of analogues of para-aminopropiophenone designed as humane rodenticides
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A number of structural analogues of the known toxicant para- aminopropiophenone (PAPP) have been prepared and evaluated for their capacity to induce methemoglobinemia - with a view to their possible application as humane pest control agents. It was found that an optimal lipophilicity for the formation of methemoglobin (metHb) in vitro existed for alkyl analogues of PAPP (aminophenones 1-20; compound 6 metHb% = 74.1 ± 2). Besides lipophilicity, this structural sub-class suggested there were certain structural requirements for activity, with both branched (10-16) and cyclic (17-20) alkyl analogues exhibiting inferior in vitro metHb induction. Of the four candidates (compounds 4, 6, 13 and 23) evaluated in vivo, 4 exhibited the greatest toxicity. In parallel, aminophenone bioisosteres, including oximes 30-32, sulfoxide 33, sulfone 34 and sulfonamides 35-36, were found to be inferior metHb inducers to lead ketone 4. Closer examination of Hammett substituent constants suggests that a particular combination of the field and resonance parameters may be significant with respect to the redox mechanisms behind PAPPs metHb toxicity.
- Rennison, David,Conole, Daniel,Tingle, Malcolm D.,Yang, Junpeng,Eason, Charles T.,Brimble, Margaret A.
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supporting information
p. 6629 - 6635
(2014/01/06)
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- Solution processable symmetric 4-alkylethynylbenzene end-capped anthracene derivatives
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New candidates composed of anthracene and 4-alkylethynylbenzene end-capped oligomers for OTFTs were synthesized under Sonogashira coupling reaction conditions. All oligomers were characterized by FT-IR, mass, UV-visible, and PL emission spectrum analyses, cyclic voltammetry (CV), differential scanning calorimetry (DSC), thermal gravimetric analysis (TGA), 1H-NMR, and 13C-NMR. Investigation of their physical properties showed that the oligomers had high oxidation potential and thermal stability. Thin films of DHPEAnt and DDPEAnt were characterized by spin coating them onto Si/SiO 2 to fabricate top-contact OTFTs. The devices prepared using DHPEAnt and DDPEAnt showed hole field-effect mobilities of 4.0 × 10-3 cm2/Vs and 2.0 × 10-3 cm2/Vs, respectively, for solution-processed OTFTs.
- Jang, Sang Hun,Kim, Hyunjin,Hwang, Min Ji,Jeong, Eun Bin,Yun, Hui Jun,Lee, Dong Hoon,Kim, Yun-Hi,Park, Chan Eon,Yoon, Yong-Jin,Kwon, Soon-Ki,Lee, Sang-Gyeong
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experimental part
p. 541 - 548
(2012/05/05)
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- Synthesis, optical, and electronic properties of soluble poly-p-phenylene oligomers as models for molecular wires
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A homologous series of soluble poly-p-phenylenes containing up to eight phenylene moieties(pp2-pp8)with branched iso-alkyl(or bis-n-alkylmethyl)groups has been synthesized and the structure-property relationship with regards to various optical and electronic properties established. All electronic and optoelectronic properties of poly-p-phenylenes followed a 1/n relationship(where n is number of phenylene moieties)with the increasing number of phenylene moieties. The low-energy electronic transition of the pp2-PP7 cation radicals, generated either by laser-flash photolysis or by chemical oxidation,varied as well according to the inverse(1/n)relationship. The observed inverse relationship of all measured electronic and optoelectronic prope rties against the increasing number of phenylene units in various ppn's, as well as X-ray crystallography of both neutral and a cation-radical salt of a representative tetra-p-phenylene oligomer allows us to demonstrate that the effective conjugation length in poly-p-phenylenes is, in part, controlled by the increasing number of interactions of ortho hydrogens which may prevent simultaneous planarization of the continuous arrays of a large number of phenylene moieties.
- Banerjee, Moloy,Shukla, Ruchi,Rathore, Rajendra
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supporting information; experimental part
p. 1780 - 1786
(2009/07/25)
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- Duplexiphane: A polyaromatic receptor containing two adjoined Δ-shaped cavities for an efficient hopping of a single silver cation
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A simple synthesis of a polyaromatic receptor (i.e., duplexiphane) containing two adjoined Δ-shaped cavities is accomplished via an intramolecular (double) McMurry coupling, and its structure is established by X-ray crystallography. The binding of silver
- Emond, Susanna J.,Debroy, Paromita,Rathore, Rajendra
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p. 389 - 392
(2008/09/19)
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- NOVEL ORGANIC SEMICONDUCTOR COMPOUND, AND ORGANIC THIN FILM TRANSISTOR USING THE SAME
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The present invention relates to novel mono- molecular organic semiconductor compounds and organic thin film transistors comprising the same. The organic semiconductor compounds according to the present invention are characterized by a structure of an acene derivative substituted with acetylene groups at both ends, a structure of anthracene derivative substituted with acetylene groups, or a structure of a multi-nuclear aromatic derivative functionalized by naphthalene having an electron-donor substituent at both ends.
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Page/Page column 33-34
(2008/12/04)
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- EP2 RECEPTOR AGONISTS
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A compound selected from Formula (iv) or Formula (iii); (iv) (1R,2S)-2[4-1(S)-hydroxyhexyl)phenyl]-5-oxo-cyclopentaneheptanoic acid [RSS] or (iii) (1R,2S)-2[4-1(R)-hydroxyhexyl)phenyl]-5-oxo-cyclopentaneheptanoic acid [RSR] or a salt, solvate, chemically protected form or prodrug thereof, and its use in treating conditions alleviated by agonism of an EP2 receptor.
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Page/Page column 43-44
(2008/06/13)
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- Aquapalladium complex: A stable and convenient catalyst for the intermolecular hydroamination of alkynes
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The intermolecular hydroamination of alkynes proceeds very smoothly in the presence of a catalytic amount of the aquapalladium complex [Pd(dppe)(H 2O)2](TfO)2. This reaction most probably proceeds through the formation of an equilibrium between the hydroxopalladium and the amidopalladium complexes, and subsequent aminopalladation of alkynes. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2005.
- Shimada, Tomohiro,Bajracharya, Gan B.,Yamamoto, Yoshinori
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- A new strategy for the enantioselective synthesis of carba-prostacyclin analogues based on organocopper conjugate addition to a bicyclic azoene and its application to the synthesis of 13,14-dinor-inter-p-phenylene carbacyclin
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An enantioselective synthesis of E/Z-13,14-dinor-inter-p-phenylene carbacyclin (E/Z-2d) by a new strategy has been realized that holds the prospect of serving as a general route for carba-prostacyclin analogues. The key intermediate in this synthesis is the bicyclic azoene Ts-9, and the key step is the regio- and stereoselective conjugate addition of the chiral arylcopper compound Cu-8d/P-n-Bu3 to the azoene with formation of hydrazone 7d. Enantioselective synthesis of azoene Ts-9 of 95% ee from ketone 4 was accomplished in four and five steps, respectively. Thus, enantioselective deprotonation of bicyclic ketone 4 with chiral base Li-10 and trapping of lithium enolate 11 with CISiMe3 gave enol ether 12, which was chlorinated with N-chlorosuccinimide (NCS) to afford chloro ketone 13. Alternatively, chloro ketone 13 was also prepared upon chlorination of 11 with NCS. Chloro ketone 13 was converted to chloro hydrazone 14, which upon treatment with a mild base furnished azoene Ts-9. Arylcopper compound 8d of 98% ee was obtained in two steps from alcohol 16, which was prepared by enantioselective reduction of ketone 17 with (-)-diisopinocampheylchloroborane. Carbacyclin derivative E/Z-2d was found to be essentially inactive as an inhibitor of ADP induced human platelet aggregation, having an |C50 of > 10 μmol/L.
- Van Bergen, Marc,Gais, Hans-Joachim
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p. 4321 - 4328
(2007/10/03)
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