Synthesis and evaluation of potent and selective β3 adrenergic receptor agonists containing heterobiaryl carboxylic acids
The design, synthesis, and SAR of a novel series of heterobiaryl phenethanolamine β3 adrenergic receptor agonists are described. The furan analogue 49 was shown to elicit a significant dose-dependent lowering of plasma glucose in a rodent model
Shearer, Barry G.,Chao, Esther Y.,Uehling, David E.,Deaton, David N.,Cowan, Conrad,Sherman, Bryan W.,Milliken, Tula,Faison, Walter,Brown, Kathleen,Adkison, Kimberly K.,Lee, Frank
p. 4670 - 4677
(2008/02/12)
AMINO ACIDS
Compounds of formula (I): Z’ -CO-A-B-NH-Z (I) wherein: Z is H or an amino protecting group; Z’ is OH, a protected or activated hydroxyl group or C1; A is an optionally substituted C5-6 arylene group; and B is an optionally substituted C5-6 arylene group.
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Page/Page column 39-40
(2008/06/13)
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