LIFE-EXTENDING AGENT, LIFE EXTENSION METHOD USING THE LIFE-EXTENDING AGENT, NOVEL DUAL OXIDASE ACTIVATOR, METHOD FOR ACTIVATING DUAL OXIDASE, PRODUCTION OF LIFE-EXTENDING AGENT, AND PRODUCTION OF DUAL OXIDASE ACTIVATOR
The present invention provides a life-extending agent comprising pyrroloquinoline quinone and/or a derivative of the pyrroloquinoline quinone.
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Paragraph 0125
(2017/10/26)
Total Synthesis of the Novel Coenzyme Methoxatin
A convergent total synthesis of the novel coenzyme methoxatin (1) is described.This coenzyme is a pyrroloquinoline quinone tailored for efficient oxidation of methanol and formaldehyde in methylotropic bacteria.The synthesis was achieved by joining pyrrole subunit 5a with uvitonic acid ester 8b followed by photocyclization of the resulting olefin 9 to deoxymethoxatin 10.Conversion of 10 to methoxatin proceeded in five steps and led to some elaboration of the chemistry of the unusual pyrroloquinoline heterocycle.The overall yield is ca. 15 percent in 11 operations.
Hendrickson, James B.,Vries, Johannes G., de
p. 1688 - 1695
(2007/10/02)
Synthesis of the Bacterial Coenzyme Methoxatin
The details of a total synthesis of methoxatin (1), the coenzyme of several bacterial alcohol dehydrogenases, are presented.Methoxatin has been prepared in 13 steps by starting from 2,3-dimethoxytoluene.The successful synthetic strategy for construction of the coenzyme used a Pfitzinger synthesis for preparation of the quinoline dicarboxylic acid portion of 1 and an "umpolung" variation of the Reissert indole synthesis for annulation of the remaining pyrrole ring.
Gainor, James A.,Weinreb, Steven M.
p. 2833 - 2837
(2007/10/02)
A Convergent Total Synthesis of Methoxatin
We report a convergent total synthesis of the coenzyme methoxatin (1) by linking pyrrole subunit (3) with uvitonic acid derivative 4d and oxidative photocyclization to deoxymethoxatin triester 6, followed by seven refunctionalization steps to 1.
Hendrickson, James B.,deVries, Johannes G.
p. 1148 - 1150
(2007/10/02)
Total Synthesis of Methoxatin, the Coenzyme of Methanol Dehydrogenase and Glucose Dehydrogenase
The first total synthesis of the bacterial coenzyme methoxatin has been successfully completed starting from readily available 2,3-dimethoxytoluene.
Gainor, James A.,Weinreb, Steven M.
p. 4317 - 4319
(2007/10/02)
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