- RETINOID COMPOUND AND PHARMACEUTICAL COMPOSITION
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PROBLEM TO BE SOLVED: To provide a novel retinoid compound that is low in teratogenicity, and a pharmaceutical composition containing said retinoid compound. SOLUTION: Provided are a retinoid compound which is a compound represented by the following formula (1) or a salt thereof, and a pharmaceutical composition containing said retinoid compound. In the formula, R1 represents a halogen atom, and R2 and R3 each independently represent a silyl group. SELECTED DRAWING: None COPYRIGHT: (C)2020,JPOandINPIT
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Paragraph 0041-0042
(2020/04/17)
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- TETRAZOLYL-CONTAINING CYCLOPROPANECARBOXAMIDES
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The present invention relates to tetrazolyl-containing cyclopropanecarboxamides compounds of general formula (I) as described and defined herein, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds fo
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Paragraph 0468-0471
(2019/06/20)
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- Discovery of pyrido[3,4-g]quinazoline derivatives as CMGC family protein kinase inhibitors: Design, synthesis, inhibitory potency and X-ray co-crystal structure
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The design and synthesis of new pyrido[3,4-g]quinazoline derivatives is described as well as their protein kinase inhibitory potencies toward five CMGC family members (CDK5, CK1, GSK3, CLK1 and DYRK1A). The interest for this original tricyclic heteroaroma
- Esvan, Yannick J.,Zeinyeh, Wael,Boibessot, Thibaut,Nauton, Lionel,Théry, Vincent,Knapp, Stefan,Chaikuad, Apirat,Loa?c, Nadège,Meijer, Laurent,Anizon, Fabrice,Giraud, Francis,Moreau, Pascale
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p. 170 - 177
(2016/05/09)
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- MODULATORS OF MITOTIC KINASES
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The invention relates to compounds of Formula (I), a prodrug, a polymorph, a tautomer, an enantiomer, a stereoisomer, a solvate, an N-oxide, or a pharmaceutically acceptable salt thereof: (formula should be inserted here) which have inhibitory effect on one or more protein kinases that are involved in cell mitosis.
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Page/Page column 53-54
(2008/12/07)
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- Guanidino substituted isoindolones as novel glycoprotein IIb-IIIa receptor antagonists
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Design and synthesis of a novel potent glycoprotein IIb-IIIa (GP IIb-IIIa) receptor antagonist based on isoindolone skeleton has been described. This scaffold has been derived from earlier reported pseudopeptides. Synthesis by a novel route has been achieved. Few molecules show very potent in vitro activity. Further identification of probable additional hydrogen bond donor site has been described.
- Lal, Bansi,Gangopadhyay, Ashok K.,Jagtap,Tanpure, Rajendra,Rao,Gupte, Ravindra D.,Subbarayan,Asudani, Gope
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p. 1815 - 1832
(2008/09/18)
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- Comparative Reactivity of Substituted 4-Nitrobenzylidene Dichlorides with Alkali
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A comparative study of the reactions of substituted 4-nitrobenzylidene dichlorides ArCHCl2 (Ar = 3-Cl-4-NO2C6H3, 2-Cl-4-NO2C6H3, 4-NO2C6H4, 3,5-Me2-4-NO2C6H2, and 2-Me-4-NO2C6H3) with aqueous alcoholic alkali shows that chlorine substitution enhances the
- Goh, Swee Hock,Kam, Toh Seok
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p. 423 - 426
(2007/10/02)
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