- A method for the regioselective synthesis of 1-alkyl-1H-indazoles
-
A method for the regioselective synthesis of 3-unsubstituted 1-alkyl-1H-indazoles, starting with 2-halobenzonitriles and N-alkylhydrazines, is described. The two-step reaction pathway proceeds through the intermediacy of 1-alkyl-3-amino-1H-indazoles follo
- Liu, Han-Jun,Hung, Shiang-Fu,Chen, Chuan-Lin,Lin, Mei-Huey
-
p. 3907 - 3912
(2013/06/27)
-
- SUBSTITUTED TETRAHYDROISOQUINOLINE COMPOUNDS AS FACTOR XIA INHIBITORS
-
The present invention provides compounds of Formula (I): or stereoisomers, pharmaceutically acceptable salts thereof, wherein all of the variables are as defined herein. These compounds are inhibitors of factor XIa and/or plasma kallikrein which may be used as medicaments.
- -
-
Paragraph 00338
(2013/04/25)
-
- DIACYLGLYCEROL ACYLTRANSFERASE INHIBITORS
-
Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, obesity, type II diabetes mellitus and metabolic syndrome.
- -
-
Page/Page column 10
(2009/04/24)
-
- PHOTOCHIMIE D'HETEROCYCLES AZOTES-VI. SYNTHESE PAR VOIE PHOTOCHIMIQUE D'AMINO ET D'ALKOXY INDAZOLES
-
The preparation of different aminoindazoles by nucleophilic aromatic photosubstitution of nitroindazoles by amines is described.In this manner, the amino, methylamino, dimethylamino and diethylamino substituents are introduced in 3, 4, 5 or 7-position.The irradiation in the presence of ethanol gives ethoxyindazoles in only four cases.Two demethylation reactions have been observed: the first one concerns the formation of methylamino derivatives starting from dimethylamine; the second one, the formation of N(H)1-indazoles by irradiation in presence of diethylamine.
- Bouchet, P.,Lazaro, R.,Benchidmi, M.,Elguero, J.
-
p. 3523 - 3534
(2007/10/02)
-