- NOVEL CURCUMIN DERIVATIVE
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The present invention provides a novel compound that is structurally similar to curcumin and has a suppressive effect on Aβ aggregation, a degradative effect on Aβ aggregates, an inhibitory effect on β-secretase, and a protective effect on neurons. The novel compound is a compound represented by the following general formula (Ia) or a salt thereof: wherein R1 represents a 4-hydroxy-3-methoxyphenyl group or the like, and R2 represents a 1H-indol-6-yl group or the like.
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Page/Page column 55
(2009/12/07)
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- Monomers containing substrate or inhibitor residues for copper amine oxidases and their hydrophilic beaded resins designed for enzyme interaction studies
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Five styrenic monomers, four with aminoalkyl residues typical of copper containing amine oxidase substrates and one with a 2,6-dialkoxybenzylamine residue which mimics previously prepared selective substrate-like benzylamine oxidase inhibitors, have been synthesized and transformed into radical homopolymers, copolymers with N,N-dimethylacrylamide (DMAA), and hydrophilic beaded resins, designed for enzyme interaction studies aimed in finding new materials for highly biospecific chromatographic separations. The five monomers have given beaded resins of 125-500 μm swellable in water with a volume increase of 1200-1500%. The four aminoalkyl monomers have given water soluble copolymers some of which are good substrates of benzylamine oxidase (BAO), diamine oxidase (DAO) and lysyl oxidase (LO), up to 9.7 times better than elastin for LO. Graphical Abstract.
- Bertini, Vincenzo,Alfei, Silvana,Pocci, Marco,Lucchesini, Francesco,Picci, Nevio,Iemma, Francesca
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p. 11407 - 11414
(2007/10/03)
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- Unexpected behavior of the methoxymethoxy group in the metalation/formylation reactions of 3-methoxymethoxyanisole
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The formation of tetrasubstituted benzenes and doubly lithiated intermediates in metalation/formylation reactions of 3-methoxymethoxyanisole has been observed with the methoxymethoxy group acting as a leaving group in some cases.
- Pocci, Marco,Bertini, Vincenzo,Lucchesini, Francesco,De Munno, Angela,Picci, Nevio,Iemma, Francesca,Alfei, Silvana
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p. 1351 - 1354
(2007/10/03)
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