- Continuous amination of propanediols in supercritical ammonia
-
Enhancements in selectivity by a factor of 4 to 18 were observed in the near critical regions of ammonia during the Co- and Ni-catalyzed synthesis of 1,3-diamino-propanes. These results are attributed to the higher concentration of ammonia at the surface of the catalyst, which favors the amination and suppresses degredation reactions.
- Fischer, Achim,Mallat, Tamas,Baiker, Alfons
-
p. 351 - 354
(2007/10/03)
-
- Synthesis, Antitumor Activity, and Chemical Properties of Silaplatin and Related Platinum(II) and Platinum(IV) Complexes Derived from β-Silyl Amines
-
Platinum(II) and platinum(IV) coordination complexes derived from β-silyl-substituted amines were prepared.The solubility of selected complexes in water and physiological saline was measured, and the effect of the β-silicon on the reactivity of the complex in aqueous solution was determined by HPLC.The stabilities of selected silyl complexes were compared to the carbon analogues.The cyclic complexes 2a ("silaplatin") and its Pt(IV) analogue, 2b, were very active against L1210 leukemia in vivo.Both the platinum(II) complex 2a and the platinum(IV) complex 2b produced a significant number of cures over the dose range 10-40 mg/kg.The platinum(II) complex 2a, silaplatin, was very active in vivo against an L1210 leukemia subline that was resistant to cisplatin; 2a was also active, when given ip against ic implanted L1210.The cyclobutanedicarboxylic acid complex 3c was synthesized; this complex was active against both cisplatin sensistive and resistant L1210 leukemia but was less potent than the analogous dichloro compound 2a.The acyclic platinum(II) and platinum(IV) complexes 1a,b were synthesized and unexpectedly found to be inactive in vivo against L1210 leukemia.More lipophilic silaplatin analogues were prepared-Pt(II) complex 2c and Pt(IV) complex 2d have one additional methylene carbon compared to 2a,b, whereas Pt(II) complex 2e and Pt(IV) complex 2f have two additional methylene carbons.Cyclization of the alkyl groups attached to the silicon gave the spiro bicyclic Pt(II) complexes 10a and 11a and the Pt(IV) complexes 10 b and 11b.
- Anderson, Wayne K.,Kasliwal, Ravindra,Houston, D. Michael,Wang, Yueh-sha,Narayanan, Ven L.,et al.
-
p. 3789 - 3797
(2007/10/03)
-
- Cosmetic composition containing an amide-amine type condensate, and a cosmetic treating process using said condensate
-
A cosmetic composition for improving the suppleness of the skin or hair and for protecting the keratin of the skin or hair from degradation by atmospheric agents or light comprises in a cosmetic or dermatologic acceptable vehicle a saturated condensate resulting from the polyaddition of a bis-acrylamide and a sterically hindered primary diamine, the condensate being saturated by hydrogenation or by addition of a thiol or an amine on the double bonds of the acrylamide residue.
- -
-
-
- Platinum complexes of aliphatic tricarboxylic acids
-
Platinum complexes of aliphatic tricarboxylic acids useful for inducing regression and/or palliation of cancer diseases in mammals.
- -
-
-
- Silicone containing bis-thioether aromatic amines
-
A silicone containing bis-thioether aromatic amine has a chemical structure wherein an aromatic nucleus at each end of the chemical radical is chemically bonded to the remainder of the chemical radical by either sulfur, sulfoxide or sulfone.
- -
-
-
