- One-pot synthesis of 1-butylpyrrolidine and its derivatives from aqueous ammonia and 1,4-butandiol over CuNiPd/ZSM-5 catalysts
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The synthesis of 1-butylpyrrolidine and its derivatives (1-butylpyrrolidine with a little of 1-butenylpyrrolidines) was developed via a one-pot method from ammonia and 1,4-butandiol. Here, the product of 1-butylpyrrolidine was emphatically investigated, and the yield was 76% under the optimized conditions. Such a route was realized through successive N-alkylation using aqueous ammonia as the nitrogen source over the CuNiPd/ZSM-5 catalyst, which was prepared by a simple incipient wetness method. In this route, 1,4-butandiol not only participated in the formation of the N-heterocycle, but also acted as an alkylating reagent. This work offers a straightforward, economical route for 1-butylpyrrolidine and its derivatives. This journal is
- Long, Yan,Liu, Shimin,Ma, Xiangyuan,Lu, Liujin,He, Yude,Deng, Youquan
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supporting information
p. 16708 - 16712
(2020/10/27)
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- Reaction of lithium eneselenolates derived from selenoamides with ketones: A highly diastereoselective synthetic route to β,β-disubstituted β-hydroxy selenoamides
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The reaction of lithium eneselenolates generated from selenoamides with a variety of ketones proceeded smoothly at -78°C to give the corresponding β,β-disubstituted β-hydroxy selenoamides in moderate to good yields. The reaction showed high diastereoselectivity. The products obtained were converted to the corresponding amides by reacting them with cyclohexene oxide.
- Murai, Toshiaki,Ishizuka, Masato,Suzuki, Akiko,Kato, Shinzi
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p. 1343 - 1346
(2007/10/03)
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- SITE-SPECIFIC GENERATION OF NONSTABILIZED α-AMINOCARBANIONS. A NOVEL METHODOLOGY TOWARD THE SYNTHESIS OF 2-AMINOALCOHOLS
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A method for site-specific generation of "nonstabilized" α-aminocarbanions with no activating or stabilizing group was developed, utilizing a metal-sulfur exchange reaction.The method provides a novel methodology for the synthesis of 2-aminoalcohols.
- Tsunoda, Tetsuto,Fujiwara, Kenshu,Yamamoto, Yo-ichi,Ito, Sho
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p. 1975 - 1978
(2007/10/02)
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