- Copper-catalyzed domino reaction between terminal alkynes, isocyanates, and oxiranes: An atom-economic route to morpholine derivatives
-
In situ generated copper acetylides react with isocyanates and oxiranes to form a decent range of morpholine derivatives. The reactions proceeded with acceptable yields and excellent regioselectivity. The presence of oxygen and moisture completely inhibit
- Beigi-Somar, Vahid,Homami, Seyed Saied,Ghazanfarpour-Darjani, Majid,Monzavi, Amirhossein
-
-
Read Online
- Synthesis of alkynamides through reaction of alkyl- or aryl-substituted alkynylaluminums with isocyanates
-
An efficient and facile method for the preparation of alkynamides through Et3N-catalyzed alumination of alkyl- or aryl-substituted terminal alkynes with AlMe3and sequential nucleophilic addition ofin situgenerated alkynylaluminums to isocyanates is described. This method has the merits of using readily available isocyanates and monosubstituted alkynes, easy access to organoaluminums, short reaction times, and high efficiency. A gram-scale synthesis of the desired alkynamide and its application to the formation of α-methylene-β-lactams demonstrates the synthetic utility of this method.
- Cho, Soohong,Lee, Yeonjoo,Lee, Kyeongmin,Lee, Hwiwoong,Lee, Yunmi,Jung, Byunghyuck
-
p. 139 - 151
(2021/12/29)
-
- Optimization and Development of a Scalable Palladium-Catalyzed C-H Activation Process for the Geometry-Selective Preparation of Kilograms of YLF466D, a Potent AMP-Activated Protein Kinase Activator
-
Adenosine 5′-monophosphate-activated protein kinase (AMPK) activator YLF466D is a promising preclinical drug candidate to treat metabolic diseases and myocardial ischemia-reperfusion injury (MIRI). Herein, we report our efforts on optimization and develop
- Yin, Jianpeng,Zhan, Desheng,Ma, Hui,Liu, Huanan,Yu, Lifang,Zhang, Yangming,Nan, Fajun
-
p. 2260 - 2269
(2021/10/21)
-
- CuCl2-catalyzed highly stereoselective and chemoselective reduction of alkynyl amides into α,β-unsaturated amides using silanes as hydrogen donors
-
A CuH-catalyzed Z-selective partial reduction of alkynyl amides to afford α,β-unsaturated amides using silane as the hydrogen donor is developed. This reaction is carried out under mild conditions and able to accommodate a broad scope of alkynyl amides in
- Duan, Lingfei,Jiang, Kai,Zhu, Hua,Yin, Biaolin
-
supporting information
p. 365 - 369
(2021/01/29)
-
- Synthesis of Succinimides via Intramolecular Alder-Ene Reaction of 1,6-Enynes
-
A novel and convenient method has been developed for the facile synthesis of functionalized succinimide derivatives via intramolecular Alder-ene reaction of 1,6-enynes. This reaction features mild and metal-free reaction conditions, which offers a green and efficient entry to synthetically important succinimide scaffolds. Preliminary mechanistic studies suggest that a diradical intermediate might be involved in this transformation.
- Chen, Xia,Lu, Yuling,Guan, Zhenhua,Gu, Lianghu,Chen, Chunmei,Zhu, Hucheng,Luo, Zengwei,Zhang, Yonghui
-
supporting information
p. 3173 - 3178
(2021/05/05)
-
- Practical access to fluorescent 2,3-naphthalimide derivatives: Via didehydro-Diels-Alder reaction
-
A practical and efficient approach for the synthesis of fluorescent 2,3-naphthalimide derivatives has been developed from readily available starting materials via an intramolecular didehydro-Diels-Alder reaction, which proceeded well under room temperature, exhibiting a wide substrate scope and good functional group tolerance. The practicability of this methodology has been verified by one-step synthesis of the environmentally sensitive fluorophore 6-DMN on a gram scale with a shorter time, fewer steps and less waste disposal, and without the utilization of toxic transition metals. The present experimental and computational studies support the crucial role of the propiolimide moiety in the transformation.
- Chen, Xia,Zhong, Cheng,Lu, Yuling,Yao, Meng,Guan, Zhenhua,Chen, Chunmei,Zhu, Hucheng,Luo, Zengwei,Zhang, Yonghui
-
supporting information
p. 5155 - 5158
(2021/05/31)
-
- Access to Triazolopiperidine Derivatives via Copper(I)-Catalyzed [3+2] Cycloaddition/Alkenyl C?N Coupling Tandem Reactions
-
A copper-catalyzed [3+2] cylcoaddition/ alkenyl C?N coupling tandem reaction was demonstrated. It provided a method for the formation of triazolopiperidine skeletons. (Figure presented.).
- Xiao, Guorong,Wu, Kaifu,Zhou, Wei,Cai, Qian
-
supporting information
p. 4988 - 4991
(2021/10/14)
-
- Interrupted aza-Wittig reactions using iminophosphoranes to synthesize 11C-carbonyls
-
A direct CO2-fixation methodology couples structurally diverse iminophosphoranes with various nucleophiles to synthesize ureas, carbamates, thiocarbamates, and amides, and is amenable for 11C radiolabeling. This methodology is practical, as demonstrated by the synthesis of >35 products and isolation of the molecular imaging radiopharmaceuticals [11C]URB694 and [11C]glibenclamide. This journal is
- Ismailani, Uzair S.,Munch, Maxime,Mair, Braeden A.,Rotstein, Benjamin H.
-
supporting information
p. 5266 - 5269
(2021/06/06)
-
- Method for synthesizing atorvastatin calcium intermediate by multi-component one-pot method
-
The invention provides a method for synthesizing an atorvastatin calcium intermediate by a multi-component one-pot method, and particularly provides a one-pot method for synthesizing 4-(4-fluorophenyl)-2-(2methylpropionyl)-3-phenyl 4-oxo-N-phenyl butyramide. The preparation method is characterized in that N-phenyl phenylpropiolamide, 4-fluorobenzaldehyde and isobutyraldehyde are synthesized by a one-pot method under the action of Cu(SbF6)2 and a Pd-ligand catalyst to obtain a target compound. The one-pot method conforms to the characteristics of green chemistry and high atom economy, and emission of three wastes and pollution factors is remarkably reduced; the reaction steps are short, and the yield (about 80-87%) is obviously higher than that of the technical scheme of the existing multi-step synthesis method; raw materials are easily available; the process operation is simple; the EHS risk is low; and the industrialized feasibility is high.
- -
-
Paragraph 0147-0151
(2020/11/23)
-
- Visible light induced the high-efficiency spirocyclization reaction of propynamide and thiophenols via recyclable catalyst Pd/ZrO2
-
A new method for the synthesis of 3-thioazaspiro[4,5]trienones was developed using Pd nanoparticle catalysts, which are highly efficient, environmentally friendly and recyclable. Alkynes and thiophene phenols are effectively cyclized by Pd/ZrO2
- Zhang, Nannan,Zuo, Hangdong,Xu, Chen,Pan, Junyi,Sun, Jun,Guo, Cheng
-
supporting information
p. 337 - 340
(2019/07/04)
-
- (: Z)-Selective anti-Markovnikov or Markovnikov thiol-yne-click reactions of an internal alkyne by amide hydrogen bond control
-
Herein, we show exclusive control of stereo and regioselective thiol-yne click (TYC) reactions of internal alkynes via amide hydrogen bond control. By exploiting appropriate hydrogen bonding interactions like N-H?S, N-H?N and C-H?O, either (Z)-selective anti-Markovnikov or Markovnikov products could be obtained for an internal alkyne, exclusively.
- Pramanik, Milan,Choudhuri, Khokan,Chakraborty, Subhayan,Ghosh, Arindam,Mal, Prasenjit
-
supporting information
p. 2991 - 2994
(2020/03/19)
-
- Time-Economical Radical Cascade Cyclization/Haloazidation of 1,6-Enynes: Construction of Highly Functional Succinimide Derivatives
-
A "time-economical" radical cascade cyclization/haloazidation of 1,6-enynes provides a direct approach to access highly functional succinimide compounds. Moderate to excellent yields along with excellent Z/E ratio were obtained under the reaction features
- Gu, Yan,Dai, Lei,Mao, Kaimin,Zhang, Jinghang,Wang, Chang,Zhao, Liming,Rong, Liangce
-
supporting information
p. 2956 - 2960
(2020/04/20)
-
- Palladium Nanoparticle-Catalyzed Stereoselective Domino Synthesis of All-Carbon Tetrasubstituted Olefin Containing Oxindoles via Carbopalladation/C-H Activation
-
The binaphthyl stabilized palladium nanoparticles (Pd-BNP) catalyzed single-step, stereoselective domino synthesis of symmetrically and unsymmetrically all-carbon tetrasubstituted olefin containing oxindoles from readily accessible anilides has been devel
- Parveen, Naziya,Sekar, Govindasamy
-
p. 10514 - 10524
(2020/09/02)
-
- Access to 3-(2-Oxoalkyl)-azaspiro[4.5]trienones via Acid-Triggered Oxidative Cascade Reaction through Alkenyl Peroxide Radical Intermediate
-
Azaspiro[4.5]trienones bearing ketone side chains at the 3-position are prepared from N-alkyl-arylpropiolamides and ketones via oxidative 1,2-difunctionalization of alkynes. The cascade sequence starts with the generation of alkenyl peroxide intermediates
- Wang, Chang-Sheng,Roisnel, Thierry,Dixneuf, Pierre H.,Soulé, Jean-Fran?ois
-
supporting information
p. 445 - 450
(2019/01/04)
-
- All Non-Carbon B3NO2 Exotic Heterocycles: Synthesis, Dynamics, and Catalysis
-
The B3NO2 six-membered heterocycle (1,3-dioxa-5-aza-2,4,6-triborinane=DATB), comprising three different non-carbon period 2 elements, has been recently demonstrated to be a powerful catalyst for dehydrative condensation of carboxylic acids and amines. The tedious synthesis of DATB, however, has significantly diminished its utility as a catalyst, and thus the inherent chemical properties of the ring system have remained virtually unexplored. Here, a general and facile synthetic strategy that harnesses a pyrimidine-containing scaffold for the reliable installation of boron atoms is disclosed, giving rise to a series of Pym-DATBs from inexpensive materials in a modular fashion. The identification of a soluble Pym-DATB derivative allowed for the investigation of the dynamic nature of the B3NO2 ring system, revealing differential ring-closing and -opening behaviors depending on the medium. Readily accessible Pym-DATBs proved their utility as efficient catalysts for dehydrative amidation with broad substrate scope and functional-group tolerance, offering a general and practical catalytic alternative to reagent-driven amidation.
- Opie, Christopher R.,Noda, Hidetoshi,Shibasaki, Masakatsu,Kumagai, Naoya
-
supporting information
p. 4648 - 4653
(2019/03/17)
-
- N-triflyl-propiolamides: Preparation and transamidation reactions
-
N-Trifluoromethylsulfonyl-propiolamides have been prepared by two methods: a) N-triflation of secondary acetylenic carboxanilides, prepared in two steps from terminal alkynes, with triflic anhydride (Tf2O) and b) from terminal alkynes and an aryl or alkyl isocyanate followed by Tf2O in a consecutive one-pot reaction. The title compounds are bench-stable and insensitive to water and alcohols but amenable to transamidation reactions with a wide range of amine nucleophiles. Conversely, they are excellent reagents for the propynoylation of ammonia, primary and secondary amines, anilines, and hydrazines.
- Fiore, Vito A.,Maas, Gerhard
-
p. 3586 - 3595
(2019/05/27)
-
- Method for preparing indolone derivative
-
The invention discloses a method for preparing an indolone derivative. The method disclosed by the invention comprises the step of subjecting phenylpropiolic acid and aniline, which serve as startingraw materials, to four steps, i.e., condensation, nucleo
- -
-
Paragraph 0058; 0059; 0060; 0061; 0062; 0066; 0069
(2018/11/03)
-
- Advanced palladium free approach to the synthesis of substituted alkene oxindoles: Via aluminum-promoted Knoevenagel reaction
-
A synthetic route for the synthesis of C24, as well as for the design of focused libraries of direct AMPK activators was developed based on a convergent strategy. The proposed scheme corresponds to the current trends in C-H bond functionalization. The use of aluminum isopropoxide for the Knoevenagel condensation of oxindole with benzophenones is a noticeable point of this work.
- Novikova, Daria S.,Grigoreva, Tatyana A.,Zolotarev, Andrey A.,Garabadzhiu, Alexander V.,Tribulovich, Vyacheslav G.
-
p. 34543 - 34551
(2018/10/24)
-
- One-pot synthesis of 3-arylaminomaleimides from terminal alkynes and isocyanates
-
The reaction of aryl acetylide anions with phenyl isocyanate and subsequent addition of a protonating agent such as ethanol affords good yields of 3-aminomaleimides, formed by the cyclization of one molecule of alkyne with two isocyanates. When the reaction is quenched with water instead, cyclopentadienone imines are formed as the major products.
- Adams, Harry,Baker, Mark,Hodson, Hannah,Morris, Michael J.
-
p. 1695 - 1698
(2017/04/06)
-
- Construction of Polycyclic γ-Lactams and Related Heterocycles via Electron Catalysis
-
Cascade radical cyclization of 1,6-enynes for the construction of biologically important polycyclic γ-lactams and related heterocycles is reported. In these radical cascade processes, three new C-C bonds are formed and transition metals are not required to run these sequences. The mild reaction conditions, broad substrate scope, and the importance of the heterocyclic products render the approach valuable.
- Xuan, Jun,Daniliuc, Constantin G.,Studer, Armido
-
supporting information
p. 6372 - 6375
(2016/12/23)
-
- Pd catalyzed insertion of alkynes into cyclic diaryliodoniums: A direct access to multi-substituted phenanthrenes
-
Cyclic diaryliodoniums remain unexplored compared to linear iodoniums. In our current work, internal alkynes were for the first time applied to react with cyclic iodoniums, catalyzed by Pd, resulting in a [4 + 2] benzannulation. Our work offers a new strategy to synthesize multi-substituted phenanthrene derivatives which are not easily accessed by conventional methods.
- Wu, Yongcheng,Wu, Fuhai,Zhu, Daqian,Luo, Bingling,Wang, Haiwen,Hu, Yumin,Wen, Shijun,Huang, Peng
-
supporting information
p. 10386 - 10391
(2015/10/28)
-
- Copper-catalyzed difunctionalization of activated alkynes by radical oxidation-tandem cyclization/dearomatization to synthesize 3-trifluoromethyl spiro[4.5]trienones
-
A copper-catalyzed difunctionalizing trifluoromethylation of activated alkynes with the cheap reagent sodium trifluoromethanesulfinate (NaSO2CF3 or Langlois' reagent) has been developed incorporating a tandem cyclization/ dearomatiza
- Hua, Hui-Liang,He, Yu-Tao,Qiu, Yi-Feng,Li, Ying-Xiu,Song, Bo,Gao, Pin,Song, Xian-Rong,Guo, Dong-Hui,Liu, Xue-Yuan,Liang, Yong-Min
-
supporting information
p. 1468 - 1473
(2015/01/30)
-
- Electrophilic ipso-iodocyclization of N-benzyl-N-(1-naphthyl)propiolamides: Synthesis of complex polycyclic lactams
-
An intramolecular electrophilic ipso-iodocyclization of N-benzyl-N-(1-naphthyl)propiolamides combined with the Friedel-Crafts-type reaction for the synthesis of complex polycyclic lactams is reported. The resulting iodinated cyclization product can provide a very useful handle for further structural manipulation. The Royal Society of Chemistry.
- Wang, Li-Jing,Zhu, Hai-Tao,Qiu, Yi-Feng,Liu, Xue-Yuan,Liang, Yong-Min
-
supporting information
p. 643 - 650
(2014/01/06)
-
- Selectivity control by silver catalysts in the cycloisomerization of 1,6-enynes derived from propiolamides
-
Silver-catalyzed cycloisomerizations of 1,6-enynes derived from propiolamides led to a selective formation of Alder-ene type 1,4-dienes. Interestingly, AgNTf2 outperformed gold or platinum catalysts in terms of selectivity and reactivity, providing the 1,4-dienes at room temperature. The presence of C(5) carbonyl group in combination with Ag salts is key to the selectivity and the β-oxo coordinated silver carbenoids were proposed as an intermediate based on the reaction profiles.
- Koo, Jaeyoung,Park, Hyun-Sub,Shin, Seunghoon
-
supporting information
p. 834 - 839
(2013/02/25)
-
- Copper-catalyzed amidation of acids using formamides as the amine source
-
Copper-catalyzed amidation of acids with formamides or acetamide for the selective synthesis of amides with the aid of 1,4-diazabicyclo[2.2.2]octane as the ligand and tert-butyl hydroperoxide as the oxidant is presented. This method is highly compatible with a wide range of acids, including alkyl acids, aryl acids, α,β-unsaturated acids, and amino acids. A general and direct route for the synthesis of amides is described. The reaction involves the copper-catalyzed amidation of acids, wherein various formamides and an acetamide are used as the amine source. Importantly, this method represents a new strategy for the direct use of acids in the synthesis of amides. DABCO = 1,4-diazabicyclo[2.2.2]octane, TBHP = tert-butyl hydroperoxide. Copyright
- Xie, Ye-Xiang,Song, Ren-Jie,Yang, Xu-Heng,Xiang, Jian-Nan,Li, Jin-Heng
-
p. 5737 - 5742
(2013/09/12)
-
- A magnesium-mediated cascade assembly for the atom-economical synthesis of bis(imidazolidine-2,4-dione)s
-
Bicycle race: Structurally complex bis(imidazolidine-2,4-dione) molecules may be synthesized with complete atom-efficiency from simple building blocks by a kinetically controlled magnesium-mediated cascade of intermolecular isocyanate insertion and intramolecular alkyne hydroamination reaction steps. Copyright
- Hill, Michael S.,Liptrot, David J.,Mahon, Mary F.
-
supporting information
p. 5364 - 5367
(2013/06/05)
-
- Development of novel alkene oxindole derivatives as orally efficacious AMP-activated protein kinase activators
-
Adenosine 5′-monophosphate-activated protein kinase (AMPK) is emerging as a promising drug target for its regulatory function in both glucose and lipid metabolism. Compound PT1 (5) was originally identified from high throughput screening as a small molecu
- Yu, Li-Fang,Li, Yuan-Yuan,Su, Ming-Bo,Zhang, Mei,Zhang, Wei,Zhang, Li-Na,Pang, Tao,Zhang, Run-Tao,Liu, Bing,Li, Jing-Ya,Li, Jia,Nan, Fa-Jun
-
supporting information
p. 475 - 480
(2013/07/25)
-
- Catalytic oxidation/C-H functionalization of N-arylpropiolamides by means of gold carbenoids: Concise route to 3-acyloxindoles
-
An efficient catalytic C-H functionalization by means of gold carbenoids for the one-step synthesis of 3-acyloxindole derivatives has been developed. The reaction proceeds efficiently with extremely good substrate scope and significant opportunities for s
- Qian, Deyun,Zhang, Junliang
-
supporting information; experimental part
p. 7082 - 7084
(2012/08/07)
-
- Efficient palladium-catalyzed Suzuki-Miyaura cross-coupling of iodoethynes with arylboronic acids under aerobic conditions
-
Ligand-free palladium-catalyzed Suzuki-Miyaura cross-coupling of iodoethynes with arylboronic acids under aerobic conditions has been developed. In the presence of palladium(II) acetate and cesium carbonate, a variety of iodoethynes underwent the Suzuki-M
- Tang, Jian-Sheng,Xie, Ye-Xiang,Wang, Zhi-Qiang,Li, Jin-Heng
-
experimental part
p. 2789 - 2795
(2011/10/18)
-
- NOVEL ALKENE OXINDOLE DERIVATIVES
-
The present invention provides compounds of formula (I), as well as pharmaceutical acceptable salt thereof, wherein R1 to R7 have the significance given herein. The compounds are useful in the treatment of prophylaxis of diseases tha
- -
-
Page/Page column 15
(2011/04/18)
-
- NOVEL ALKENE OXINDOLE DERIVATIVES
-
A compound of formula (I), the pharmaceutically acceptable salt, the pharmaceutical composition, the preparation method and the use thereof.
- -
-
Page/Page column 32-33
(2011/04/19)
-
- ALKENE OXINDOLE DERIVATIVES AND THEIR USES TO TREAT OBESITY, DIABETES AND HYPERLIPIDEMIA
-
A compound of formula (I) as well as pharmaceutically acceptable salt thereof, wherein R1 to R7 have the significance given in claim 1, can be used as a medicament.
- -
-
Page/Page column 31-32
(2011/04/19)
-
- Pyrroles and indolizidines from deprotonated α-(alkylideneamino) nitriles
-
Their ready availability from simple starting materials in only two synthetic steps and their versatility as building blocks for the construction of highly substituted amines and N-heterocycles renders α-(alkylideneamino) nitriles useful synthetic intermediates. Herein, short syntheses of tri- and tetrasubstituted pyrroles including the northern half of the HMG-CoA reductase inhibitor atorvastatin as well as an access to 3-substituted indolizidines will be described. Georg Thieme Verlag Stuttgart - New York.
- Schaefer, Ines,Opatz, Till
-
experimental part
p. 1691 - 1704
(2011/07/29)
-
- An efficient synthesis of N3,4-diphenyl-5-(4-fluorophenyl)-2-isopropyl-1H- 3-pyrrolecarboxamide, a key intermediate for atorvastatin synthesis
-
An efficient synthesis of N3,4-diphenyl-5-(4-fluorophenyl)-2-isopropyl-1H- 3-pyrrolecarboxamide, a key intermediate for the synthesis of an effective HMG-CoA reductase inhibitor atorvastatin, is described. The synthesis is based on the 1,3-dipolar cycload
- Pandey, Pramod S.,Rao, T. Srinivasa
-
p. 129 - 131
(2007/10/03)
-
- Superacidic activation of α,β-unsaturated amides and their electrophilic reactions
-
The electrophilic reactivity of α,β-unsaturated amides towards weak nucleophiles such as arenes and cyclohexane, initiated either with triflic acid (CF3SO3H) or with excess AlCl3, has been studied. The amides generally condense readily with aromatics in the presence of AlCl3 to give 3-arylpropionamides and related compounds in excellent yields, while some amides also undergo selective ionic hydrogenation with cyclohexane to give saturated amides. The proposed mechanism of these reactions involves dicationic intermediates (superelectrophiles). The direct observation of a dicationic species (by low-temperature NMR) is reported. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004.
- Koltunov, Konstantin Yu.,Walspurger, Stephane,Sommer, Jean
-
p. 4039 - 4047
(2007/10/03)
-
- Superelectrophilic activation of polyfunctional organic compounds using zeolites and other solid acids
-
Zeolites and other available solid acids have been successfully applied to initiate reactions, which were earlier recognised to involve superelectrophilic intermediates and thus required excess of superacids to be carried out.
- Koltunov, Konstantin Yu.,Walspurger, Stéphane,Sommer, Jean
-
p. 1754 - 1755
(2007/10/03)
-
- Process of preparing substituted acrylamides
-
The present invention relates to a process for preparing acrylamides; wherein, a propiolamide is reacted with an activated aromatic ring to yield a wide variety of acrylamides.
- -
-
-
- Zeolite-HY : A selective and efficient catalyst for the synthesis of amides under microwave irradiations
-
An efficient and selective method for the conversion of various acids into their corresponding amides in the presence of zeolite under microwave irradiation is described. The reaction proceeds efficiently at ambient pressure in high yields.
- Gadhwal, Sunil,Dutta, Manu Prakash,Boruah, Anima,Prajapati, Dipak,Sandhu, Jagir S.
-
p. 725 - 727
(2007/10/03)
-
- 2,5-diarylisothiazolone: Novel inhibitors of cytokine-induced cartilage destruction
-
A series of 2,5-diarylisothiazolones is reported that inhibit the IL-1β- induced breakdown of bovine nasal septum cartilage in an organ culture assay. The synthesis and preliminary SAR of these compounds are described. These compounds represent a novel, n
- Wright, Stephen W.,Petraitis, Joseph J.,Freimark, Bruce,Giannaras, John V.,Pratta, Michael A.,Sherk, Susan R.,Williams, Jean M.,Magolda, Ronald L.,Arner, Elizabeth C.
-
p. 851 - 858
(2007/10/03)
-
- Facile and Effective Synthesis of Unusually Substituted Aromatic N-Phenylamides
-
A mild and effective new method for the preparation of a variety of arylamides 3a-i as well as heterocyclic 5a, b and 6 and olefinic amides 7, 9 is described.The reaction of trialkylstannyl-substituted aromatic, heterocyclic or vinylic hydrocarbons with aryl isocyanates in the presence of aluminium trichloride provides the corresponding N-aryl-substituted amides in good to excellent yields.The stannyl group serves as a powerful leaving group superior to hydrogen by several powers of ten which allows, via ipso substitution, to obtain isomer patterns not accessible by normal electrophilic substitution reactions, e. g. substitution in meta position with respect to a methoxy group.
- Kobs, Uwe,Neumann, Wilhelm P.
-
p. 2191 - 2194
(2007/10/02)
-
- TRANS-6-[2-(3- OR 4-CARBOXAMIDO-SUBSTITUTED PYRROL-1-YL)ALKYL]-4-HYDROXYPYRAN-2-ONE INHIBITORS OF CHOLESTEROL SYNTHESIS
-
Certain trans-6-2-(3-or 4-carboxamido-substituted pyrrol-1-yl) alkyl!-4-hydroxypyran-2-ones and the corresponding ring-opened acids derived therefrom which are potent inhibitors of the enzyme 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG CoA reduct
- -
-
-