- Syntheses of polyalkylated imidazoles
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We have developed improved general simple methods for large-scale preparation of polyalkylated imidazoles by improved multicomponent synthesis from commercially available starting materials. A large range of NH- and N-alkyl-polyalkylimidazoles (40 in total, including novel compounds) has been synthesized.
- Evjen, Sigvart,Fiksdahl, Anne
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supporting information
p. 1392 - 1399
(2017/07/25)
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- Synthesis of 4,5-substituted imidazoles by a fast condensation of 1,2-diketones and urotropine in heterogeneous medium
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Starting from 1,2-diketones and urotropine in the presence of ammonium acetate, a simple and efficient solventless microwave-assisted synthesis of 4,5-disubstituted imidazoles was accomplished. Georg Thieme Verlag Stuttgart.
- Bratulescu, George
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experimental part
p. 2319 - 2320
(2010/02/28)
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- A Two-Step Synthesis of Imidazoles from Aldehydes via 4-Tosyloxazolines
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Imidazoles with substituents in the 4- and 4,5-positions were prepared by heating 4-tosyloxazolines in saturated methanolic ammonia.Similar treatment of these oxazolines with monoalkylamines regioselectively affords 1,4-disubstituted imidazoles.When oxazolines bearing an ethyl group at the 4-position were heated with alkylamines, however, a regioisomeric mixture of di- or trisubstituted imidazoles was produced.These reactions proceed via an intermolecular condensation of α-amino ketones and amidines or intramolecular cyclization of α-amidino ketone intermediates, respectively.
- Horne, David A.,Yakushijin, Kenichi,Buechi, George
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p. 139 - 154
(2007/10/02)
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