- Effect of Transition Metals on Chemodivergent Cross-Coupling of Acrylamides with Vinyl Acetate via C-H Activation
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A novel chemodivergent cross-coupling of acrylamides and vinyl acetates has been realized via metal-catalyzed vinylic C-H activation. The selective olefinic C-H vinylation and alkenylation reaction was examined with a variety of differently functionalized acrylamides. The reaction efficiently generates a range of highly synthetically valuable butadienes with good functional group tolerance in good to moderate yields. A possible catalytic reaction mechanism involving the chelation-assisted olefinic C-H activation via an acetate-assisted deprotonation pathway is proposed.
- Logeswaran, Ravichandran,Jeganmohan, Masilamani
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supporting information
p. 5679 - 5683
(2021/08/03)
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- TRISUBSTITUTED FUROPYRIMIDINES AND USE THEREOF
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The invention relates to the novel 4,5,6-trisubstituted furo[2,3-d]pyrimidine derivatives of formula (I), to methods for their production, their use in the treatment and/or prophylaxis of diseases and their use in the production of drugs for the treatment
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Page/Page column 18-19
(2010/11/03)
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- N-alkylation of methacrylamide with alkyl halides
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N-Alkylation of methacrylamide with ethyl bromide, ethyl iodide, and allyl bromide in acetonitrile in the presence of alkalis yields N- and N,N-substituted methacrylamides. The effect of temperature, reactant ratio, nature of the alkyl halide, and water content on the reaction course was studied.
- Shirshin,Kazantsev,Kazakov,Danov
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p. 1418 - 1420
(2007/10/03)
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