Synthetic chemistry-led creation of a difluorinated biaryl ether non-nucleoside reverse transcriptase inhibitor
In the process of developing a series of novel, fluorinated biaryl ether NNRTIs, we fortuitously discovered derivative 20, which possesses excellent potency against both wild-type and clinically relevant mutations of the reverse transcriptase enzyme. The
Jones, Lyn H.,Randall, Amy,Barba, Oscar,Selby, Matthew D.
p. 3431 - 3433
(2008/09/19)
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