- Rational size control of gold nanoparticles employing an organometallic precursor [Au-C≡C-t-Bu]4 and tunable thiolate-functionalized ionic liquids in organic medium
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Gold nanoparticles (Au NPs) stabilized with six different thiolate-functionalized ionic liquids (TFILs) were synthesized in an organic solvent. The size and optical properties of the TFIL-stabilized Au NPs can be rationally controlled by altering the N-alkyl chain length and (or) the counteranion of the TFIL-stabilizing ligand. Au NPs were prepared from the reduction of a gold precursor (HAuCl4 or [Au-C≡C-t-Bu] 4) employing NaBH4 in the presence of the different disulfide precursors. A model, based on Israelachvili theory, is proposed to account for the dependence of NP size on the N-alkyl chain length and the counteranion of the surfactantlike TFIL stabilizers.
- Luska, Kylie L.,Moores, Audrey
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scheme or table
p. 145 - 152
(2012/03/07)
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- F18-labeled thia fatty acids and methods of making and using the same
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Sulfur heteroatom substitution at the C4 position of18F-labeled fatty acids yields a tracer that is retained in proportion to the beta-oxidation rates in mammalian tissue, particularly hypoxic myocardium. Most preferably, the invention is embodied in an [18F]fluoro-4-thia-fatty acid having a chain length of between 8 to 20 carbon atoms. The18F-labeled 4-thia fatty acids of this invention find particular utility the radiolabelling of tissue sites (e.g., myocardium) for purposes of positron emission tomography.
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- Organic monolayers as nucleation sites for epitaxial growth: II. Synthesis of ω-N-pyrrolo-functionalized n-dialkyl disulfide
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Pyrrole terminated dialkyl disulfides were synthesized. The molecules self assemble on gold and can be used for the electrochemical epitaxial growth of poly(n-alkyl)pyrrole.
- Zong, Kyukwan,Brittain, Scott T.,Wurm, D. Brad,Kim, Yeon-Taik
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p. 157 - 162
(2007/10/03)
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- Synthesis and Antiestrogenic Activity of Diaryl Thioether Derivatives
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The reaction of 1,2-diarylethanol and mercapto side chain catalyzed by ZnI2 was used as a key step in the short (three to five steps) and efficient synthesis of 17 diaryl thioether derivatives.Several of these compounds contain a methyl butyl amide chain and an hydroxyaryl moiety, respectively, for antiestrogenic activity and binding affinity on estrogen receptor.No binding affinity for crude cytosolic preparation of the estrogen receptor was observed for compounds without phenolic group, while a low affinity (0.01-0.05percent) was measured for mono- or diphenol derivatives.Like the pure steroidal antiestrogen EM-139, these novel nonsteroidal compounds did not exert any stimulatory effect on cell proliferation of (ER+) ZR-75-1 human breast cancer cells and partially reversed the amplitude of the stimulatory effect induced by estradiol on this (ER+) cell line.No proliferative or antiproliferative effect on (ER-) MDA-MB-231 human breast cancer cells was also observed for three of these compounds (39-41).Among the newly synthesized nonsteroidal compounds, the thioether derivative 41 (N-butyl-N-methyl-13,14-bis(4'-hydroxyphenyl)-12-thiatetradecanamide), with a long methylbutylalkanamide side chain and a diphenolic nucleus, was selected as the best antiestrogenic compound.However, this compound was 100-fold less antiestrogenic in (ER+) ZR-75-1 cells than the steroidal antiestrogen EM-139.
- Poirier, Donald,Auger, Serge,Merand, Yves,Simard, Jacques,Labrie, Fernand
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p. 1115 - 1125
(2007/10/02)
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- Tensio-active polypod compounds, process for preparing them and compositions containing them
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Tensio-active cyclic polyethers of the general formula: STR1 where A refers to a hydrophile block chosen from the amine, ammonium, ammonio alkyl carboxylate, ammonio alkyl sulfonate, amide, sulfonamide, ether, thioether, hydroxyl, ester and acid groupings. These polyethers may be prepared (1) by reaction of alcohol or of undecylenic acid with thioacetic acid, (2) saponification with an alkaline base, (3) reaction of the product obtained in (2) with the tetramer of epichlorohydrin or of epibromohydrin, (4) reaction of mesylate or tosylate of the compound obtained in (3) either (a) with dimethylamine or methylethanolamine, the resulting compound being able to be salified or alkylated, or (b) with the mercapto ethanol or mercapto glycerol; the compounds thereby obtained being then able to be submitted to reactions of polyaddition of ethylene oxide and/or of glycidol oxide. These tensio-active cyclic polyethers are suitable for use in the cosmetic, textile, insecticide and similar industries.
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