cas 73836-78-9, LEUKOTRIENE D4 | Articles data

Articles about 73836-78-9Total 7 be found

Total synthesis of leukotrienes from butadiene
The total synthesis of leukotrienes has been achieved starting from butadiene by a palladium-catalyzed telomerization at room temperature. A Sharpless catalytic asymmetric epoxidation generated the asymmetric centers with >94% ee. Simple transformations of the key intermediate 15 produced the leukotrienes LTA4 methyl ester (4), LTC4 (1), LTD4 (2) and LTE4 (3), as well as (14S, 15S)-LTA4 methyl ester (24) and the novel [2H2]-LTA4 methyl ester (28). The use of the opposite chiral director in the Sharpless catalytic asymmetric epoxidation gave the key intermediate 15a that has been used in the synthesis of the double epimers of the leukotrienes as well as LTB4.
Rodriguez, Ana,Nomen, Miguel,Spur, Bernd W.,Godfroid, Jean-Jacques,Lee, Tak H.
p. 2991 - 3000
(2007/10/03)

Method alleviating migraine headache with mast cell degranulation blocking agents
A method of preventing or alleviating a migraine headache which comprises administering a pharmaceutically effective amount of a mast cell degranulation blocking agent just prior to or during the prodromal phase of the migraine in the absence of an analgesic. The agent can also be administered in combination with a central nervous system stimulant.
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(2008/06/13)

CHEMICAL CONVERSION OF ARACHIDONIC ACID TO SLOW REACTING SUBSTANCES
The synthesis of slow reacting substances, leukotrienes C, D, and E, can be accomplished conveniently by a stereoselective biomimetic route.Details are provided for the conversion of 5-HPETE methyl ester 4 to leukotriene methyl ester (2) and thence to leukotrienes C and D.
Corey, E. J.,Barton, Alan E.
p. 2351 - 2354
(2007/10/02)

SYNTHESIS OF LEUKOTRIENES - NEW SYNTHESIS OF NATURAL LEUKOTRIENE A4
The acetonides of D- or L-glyceraldehyde are chiral synthons for an efficient and versatile synthesis of the natural leukotrienes A4, C4, D4 and E4 and equally can be used to prepare the corresponding unnatural analogues.
Rokach, Joshua,Young, Robert N.,Kakushima, Masatoshi,Lau, Cheuk-Kun,Seguin, Rick,at al.
p. 979 - 982
(2007/10/02)

Total synthesis of slow reacting substances (SRS). "Leukotriene C-2" (11-trans-leukotriene C) (3) and leukotriene D (4)
Syntheses are described for the "slow reacting substances" 11-trans-leukotriene C (3) (previously known as leukotriene C-2) and leukotriene D (4), the cys-gly analog of leukotriene C (2). The synthesized leukotrienes 3 and 4 were instrumental in the assignment of structure to these members of the family of naturally occuring slow reacting substances which includes also 2.
Corey,Clark, David A.,Marfat, Anthony,Goto, Giichi
p. 3143 - 3146
(2007/10/02)

TOTAL SYNTHESIS OF SLOW REACTING SUBSTANCES (SRS's):6-EPI-LEUKOTRIENE C AND 6-EPI-LEUKOTRIENE D
6-Epi-leukotrienes C and D (3 and 4) have been synthesized unambigously via the 5(S),6(R)-epoxide (5,6-cis) wich is isomeric with leukotriene A.These 6-epi-leukotrienes are less active (especially 4) than leukotrienes C and D(1 and 2) and have not been fo
Corey, E. J.,Goto, Giichi
p. 3463 - 3466
(2007/10/02)