cas 7387-98-6, D-erythro-Chloramphenicol | Articles data

Articles about 7387-98-6Total 5 be found

Oxidant controlled regio- and stereodivergent azidohydroxylation of alkenes via I2 catalysis
A novel, I2 catalyzed regio- and stereodivergent vicinal azidohydroxylation of alkenes leading to 1,2-azidoalcohols in high yields (up to 92%) and excellent dr (up to 98%) has been developed. This unprecedented transformation employs NaN3 and DMF as N- and O-nucleophiles respectively. The role of DMF as the O-source in the reaction has been unequivocally proven by 18O labelling studies.
Prasad,Reddi,Sudalai
supporting information
p. 10276 - 10279
(2015/06/25)

Direct synthesis of β-hydroxy-α-amino acids via diastereoselective decarboxylative aldol reaction
A straightforward metal-free synthesis of anti-β-hydroxy-α-amino acids is described. The organic base-mediated decarboxylative aldol reaction of cheap, readily available α-amidohemimalonates with various aldehydes afforded under very mild conditions anti-β-hydroxy-α-amido esters in high yields and complete diastereoselectivity. Simple one-pot subsequent transformations enabled the corresponding anti-β-hydroxy-α-amino acids or in a few examples their syn diastereomers to be obtained directly using epimerization conditions.
Singjunla, Yuttapong,Baudoux, Jeroime,Rouden, Jacques
p. 5770 - 5773
(2013/12/04)

Organocatalytic aziridine synthesis using F+ salts
This paper describes a unique application of the fluoronium cation (F +) as an organocatalyst for mediating the reaction between N-substituted imines and ethyl diazoacetate affording excellent yields of N-substituted aziridines.
Bew, Sean P.,Fairhurst, Shirley A.,Hughes, David L.,Legentil, Laurent,Liddle, John,Pesce, Paolo,Nigudkar, Sanket,Wilson, Martin A.
supporting information; experimental part
p. 4552 - 4555
(2009/12/05)

Synthesis of chloramphenicol via a new intermediate 4-para-nitrophenyl- 5-formamido-1,3-dioxane
4-Phenyl-5-amino-1,3-dioxane 4, obtained from β-bromo styrene 2 was protected as formamido derivative 5. Nitration of 5 followed by regioselective acylative cleavage of the nitro product 12 gave N-formyl-N- acetyl hemiacetal diacetate 16, which on sequential base and acid hydrolysis followed by dichloroacetylation gave chloramphenicol 1.
Hazra, Braja G.,Pore, Vandana S.,Maybhate, Shailaja P.
p. 1857 - 1864
(2007/10/03)

REGIOSELECTIVE ACYLATIVE CLEAVAGE OF CYCLIC FORMAL OF CHLORAMPHENICOL
The amide 6 has been synthesised by reacting the amine 3 with dichloroketene in situ.This amide 6 on nitration gave formal 7, which when reacted with acetic anhydride and p-toluene sulfonic acid underwent regioselective cleavage of the dioxane ring to furnish the hemiacetal 11.This on treatment with methanol-water-ammonia yielded chloramphenicol 2.
Hazra, B. G.,Pore, V. S.,Maybhate, S. P.,Natekar, M. V.,Rao, A. S.
p. 1763 - 1770
(2007/10/02)