- SUBSTITUTED NUCLEOSIDES, NUCLEOTIDES AND ANALOGS THEREOF
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Disclosed herein are nucleotide analogs, methods of synthesizing nucleotide analogs and methods of treating diseases and/or conditions such as a Picornaviridae and/or Flaviviridae viral infections with one or more nucleotide analogs.
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Paragraph 0304
(2018/03/06)
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- A (2 'R) -2' - deoxy -2 '- fluoro -2' - methyl urea glucoside preparation method (by machine translation)
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The invention discloses a (2 'R) -2' - deoxy -2 '- fluoro -2' - methyl urea glucoside (type I) synthetic method. Cheap and easily available starting material, through the hydroxyl protection, cyclization, the links such as fluoride, obtains the type I compound. (by machine translation)
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Paragraph 0029
(2017/02/28)
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- Synthesis and Evaluation of 2,6-Modified Purine 2′-C-Methyl Ribonucleosides as Inhibitors of HCV Replication
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A variety of 2,6-modified purine 2′-C-methylribonucleosides and their phosphoramidate prodrugs were synthesized and evaluated for inhibition of HCV RNA replication in Huh-7 cells and for cytotoxicity in various cell lines. Cellular pharmacology and HCV polymerase incorporation studies on the most potent and selective compound are reported.
- Zhou, Longhu,Zhang, Hongwang,Tao, Sijia,Ehteshami, Maryam,Cho, Jong Hyun,McBrayer, Tamara R.,Tharnish, Philip,Whitaker, Tony,Amblard, Franck,Coats, Steven J.,Schinazi, Raymond F.
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supporting information
p. 17 - 22
(2016/02/03)
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- SYNTHESIS OF SACCHARINIC ACID DERIVATIVES
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Hydroxylation of ethyl cis-2,3-dideoxy-4,5-O-isopropylidene-2-C-methyl-DL-glycero-pent-2-enonate (1) with osmium tetraoxide gave ethyl 4,5-O-isopropylidene-β-DL-galactosaccharinate (ethyl 4,5-O-isopropylidene-2-C-methyl-DL-lyxonate, 3) and ethyl 4,5-O-isopropylidene-α-DL-glucosaccharinate (ethyl 4,5-O-isopropylidene-2-C-methyl-DL-ribonate, 4).Similarly, the trans-isomer of 1 yielded a mixture of ethyl 4,5-O-isopropylidene-α-DL-galactosaccharinate (ethyl 4,5-O-isopropylidene-2-C-methyl-DL-xylonate, 5) and ethyl 4,5-O-isopropylidene-β-DL-glucosaccharinate (ethyl 4,5-O-isopropylidene-2-C-arabinonate, 6).Compounds 3-6 were transformed into the corresponding 1,4-lactones.
- Aparicio, Fidel J. Lopez,Cubero, Isidoro Izquierdo,Olea, Maria D. Portal
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