One-pot Synthesis of Protected Alkylhydrazines from Acetals and Ketals. Scope and Limitations
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Mastitski, Anton,Niinepuu, Siret,Haljasorg, T?iv,J?rv, Jaak
p. 490 - 498
(2015/11/09)
Solvent-free synthesis of hydrazones and their subsequent N-alkylation in a Ball-mill
A large variety of Boc-, Bz-, Ts-, and Fmoc- protected hydrazones were prepared via condensation of an equimolar amount of carbonyl-compound and the corresponding hydrazine using a ball-mill. Hydrazones were always obtained in a quantitative yield and no solvents were used at any step. In a second step, we realized the first solvent-free N-allylation and N-benzylation of these hydrazones.