Anti-allergy activity of 10-oxo-10H-pyridazino[6,1-b]quinazoline-2-carboxylic acids
A series of substituted 10-oxo-10H-pyridazino[6,1-b]quinazoline-2-carboxylic acids was prepared and evaluated as anti-allergy agents. The 8-chloro and unsubstituted analogues were more potent than cromolyn sodium and doxantrazole intravenously in the rat PCA test. None of the analogues possessed significant oral activity.
The invention relates to substituted 10-oxo-10H-pyridazino(6,1-b)quinazoline-2-carboxylic acids having the formula: STR1 wherein R1 is hydrogen, halogen; R2 is hydrogen, lower alkyl containing one to three carbon atoms, or wherein R1 and R2 taken together with the carbon atoms to which they are attached in a benzo ring, and the pharmaceutically acceptable salts thereof. These compounds are useful as anti-allergic agents.
-
(2008/06/13)
More Articles about upstream products of 74163-11-4