Synthesis and structure-activity studies of novel benzocycloheptanone oxazolidinone antibacterial agents
We describe a novel class of benzocycloheptanone derived oxazolidinone antibacterial agents. The synthesis and antibacterial activities with structure variation is discussed.
Vara Prasad,Boyer, Frederick E.,Chupak, Lou,Dermyer, Michael,Ding, Qizhu,Gavardinas,Hagen, Susan E.,Huband, Michael D.,Jiao, Wenhua,Kaneko, Takushi,Maiti, Samarendra N.,Melnick, Michael,Romero, Karina,Patterson,Wu, Xiujuan
Compounds of formula I and methods for their preparation are disclosed. Further disclosed are methods of making biologically active compounds of formula I as well as pharmaceutically acceptable compositions comprising compounds of formula I. Compounds of formula I as disclosed herein can be used in a variety of applications including use as antibacterial agents.
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(2010/02/08)
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