- Preparation method of anti-infection cephalosporin drug
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The invention discloses a preparation method of an anti-infection cephalosporin drug. The method comprises the following steps: reacting 7-MAC(II) with 2-oxoacetic acid hydrate to prepare a compound III, carrying out thioacetalation reaction on the compound III and 2-carbamoyl-3, 3-dimercaptoacrylic acid to prepare a compound IV, and carrying out deprotection and salification to prepare cefotetan disodium (I). The synthetic route is simple, the reaction condition is mild, the generation of impurities is reduced, the total yield and purity of the product are improved, and the method is suitable for industrial production.
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Paragraph 0017; 0046-0049
(2021/05/05)
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- Preparation method of cefotetan disodium bulk drug
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The invention discloses a preparation method of a cefotetan disodium bulk drug, which comprises the following steps: reacting 7-MAC (II) with 2, 2-dimercaptoacetic acid to prepare a compound III, reacting the compound III with 3-amino-2-formyl -3-oxo sodium propionate to prepare a compound IV, and carrying out deprotection and salification to obtain cefotetan disodium (I). The preparation method is simple and convenient, the reaction conditions are mild, and the obtained cefotetan disodium bulk drug is high in purity and suitable for industrial production.
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