Synthesis and Biological Activity of Some Substituted 3-carbostyrils and Carbostyril-3-(2'-heteroarylidene)carbohydrazides
Several 1-alkyl-4-acetoxy-3-carbostyrils (IIIa-f) and 1-alkyl-4-hydroxycarbostyril-3-(2'-heteroarylidene)carbohydrazides (IVa-f) have been prepared and evaluated for their biological activities.Some of the compounds reported display moderate anti-amoebic and anti-inflammatory activities.The heteroarylidene derivative (IVb) is found to possess antitrichomonal activity in vitro comparable to that of metronidazole.However, all these compounds are completely inactive against bacteria, fungi and helminths.
Shridhar, D. R.,Sastry, C. V. Reddy,Mehrotra, A. K.,Nagarajan, R.,Lal, B.,Bhopale, K. K.
p. 59 - 61
(2007/10/02)
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