- Synthesis of multifunctional coupling agents and their selective reactions with hydroxy and amino groups in the melt
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Three new coupling agents with different numbers of N-acyl lactam and 4H-3,1-benzoxazin-4-one groups were synthesized. A selective stepwise conversion of the coupling agents with 1-dodecanol and 1-dodecylamine was demonstrated by means of solvent-free model reactions in melt at 195 and 210 °C, respectively. These coupling agents are regarded as potential cores for the synthesis of novel star-like compounds and polymers with defined arms varying in type and lengths.
- Zhang, Haiping,Jakisch, Lothar,Komber, Hartmut,Voit, Brigitte,B?hme, Frank
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p. 3656 - 3663
(2013/05/08)
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- Biological evaluation of bisbenzaldehydes against four Mycobacterium species
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A series of bisbenzaldehydes and structurally related analogs, conveniently synthesized via microwave-assisted reactions, were evaluated in vitro against drug susceptible and multi-drug resistant Mycobacterium tuberculosis, against virulent Mycobacterium bovis, against Mycobacterium ulcerans and against two Mycobacterium avium subspecies. Among the 33 substances that were tested, compound 12, i.e. 4,4′-[1,12-dodecanediyl(oxy)]bisbenzaldehyde, emerged as the most promising hit. Its activity was further confirmed in an intracellular growth inhibition assay of M. tb in murine J774 A.1 macrophages. None of the compounds showed significant cytotoxicity on human C3A hepatocytes in a neutral red dye uptake assay and no genotoxicity or mutagenicity was observed as demonstrated by a VITOTOX test and confirmed with a comet assay.
- Cappoen, Davie,Forge, Delphine,Vercammen, Frank,Mathys, Vanessa,Kiass, Mehdi,Roupie, Virginie,Anthonissen, Roel,Verschaeve, Luc,Vanden Eynde, Jean Jacques,Huygen, Kris
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p. 731 - 738
(2013/07/25)
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- Synthesis and Thermotropic Properties of Twin Mesogens Containing a Polymethylene Spacer
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DSC and microscopic data are presented for a thermotropic twin mesogen series.Deviations from normal trends were observed.
- Aguilera, C.,Ahmad, S.,Bartulin, J.,Mueller, H. J.
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p. 277 - 282
(2007/10/02)
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