- Synthesis of gem-difluorocyclopentane/hexane building blocks
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An approach to the preparation of gem-difluorocyclopentane/hexane-derived carboxylic acids and amines is described. Whereas for 3,3-difluoro-substituted cycloalkanones, straightforward deoxofluorination of the corresponding ketoesters led to the target compounds, in the case of 2,2-difluoro isomers, the bypass or alternative routes were necessary.
- Melnykov, Kostiantyn P.,Nosik, Pavel S.,Kurpil, Bohdan B.,Sibgatulin, Dmitriy A.,Volochnyuk, Dmitriy M.,Ryabukhin, Sergey V.,Grygorenko, Oleksandr O.
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- The enantioselective synthesis of tetracyclic methyllycaconitine analogues
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A new enantioselective synthesis of ABEF ring analogues of methyllycaconitine has been developed using a chiral cobalt(III) salen-catalyzed Diels-Alder reaction to form the B ring. Subsequent elaboration to form the A, E and F rings was achieved by sequential Dieckmann, Mannich and Wacker-type cyclizations to afford tetracyclic analogues in 97.5% ee.
- Sparrow, Kevin,Barker, David,Brimble, Margaret A.
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p. 7989 - 7999
(2011/11/07)
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- A NEW SYNTHESIS OF α-METHYLENE CARBONYL COMPOUNDS
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α-Methylene carbonyl compounds are regioselectively prepared by the reaction of α-nitroketones or α-nitroesters with 37percent formaldehyde in the presence of a catalytic amount of weak bases followed by acetylation, denitration with Bu3SnH, and elimination of acetic acid.
- Ono, Noboru,Miyake, Hideyoshi,Fujii, Masayuki,Kaji, Aritsune
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p. 3477 - 3480
(2007/10/02)
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