Compelling P1 substituent affect on metalloprotease binding profile enables the design of a novel cyclohexyl core scaffold with excellent MMP selectivity and HER-2 sheddase inhibition
A serendipitous discovery that the metalloprotease binding profile of a novel class of 2-carboxamide-3-hydroxamic acid piperidines could be significantly attenuated by the modification of the unexplored P1 substituent enabled the design and synthesis of a
Construction of bicyclo[2.2.2]octane ring system via homoallyl-homoallyl radical rearrangement
We designed a sequential three-step, one-pot reaction (homoallyl- homoallyl radical rearrangement reaction) to generate highly functionalized bicyclo[2.2.2]octane ring system, and succeeded in developing a novel synthetic method to bicyclo[2.2.2]octane compounds from simple cyclohexene derivatives.
Toyota, Masahiro,Yokota, Masahiro,Ihara, Masataka
p. 1551 - 1554
(2007/10/03)
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