Nitrosopurines en route to potently cytotoxic asmarines
A nitrosopurine ene reaction easily assembles the asmarine pharmacophore and transmits remote stereochemistry to the diazepine-purine hetereocycle. This reaction generates potent cytotoxins which exceed the potency of asmarine A (1.2 μM IC50) and supersede the metabolites as useful leads for biological discovery.
Wan, Kanny K.,Iwasaki, Kotaro,Umotoy, Jeffrey C.,Wolan, Dennis W.,Shenvi, Ryan A.
p. 2410 - 2415
(2015/03/04)
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