- A facile 2: H -chromene dimerization through an ortho -quinone methide intermediate catalyzed by a sulfonyl derived MIL-101 MOF
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A MIL-101-SO3H MOF was synthesized using commercially available materials. The as-synthesized MIL-101-SO3H was characterized by SEM, XRD, FTIR, BET and TGA. An efficient and diastereoselective homo-dimerization of 2H-chromenes cataly
- Du, Xin,Li, Xiujuan,Tang, Houliang,Wang, Wenyu,Ramella, Daniele,Luan, Yi
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p. 12722 - 12728
(2018/08/04)
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- Iron-catalyzed rearrangements and cycloaddition reactions of 2h-chromenes
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Iron(III) salts catalyze the tandem rearrangement/hetero-Diels-Alder reaction of 2H-chromenes to yield tetrahydrochromeno heterocycles. The process can occur as a homodimerization and cycloaddition process using electron-rich dienophiles. Deuterium labeli
- Huan Sun, Yi Luan,Schaus, Scott E.
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supporting information; experimental part
p. 6480 - 6483
(2012/02/01)
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- PET imaging of nobiletin based on a practical total synthesis
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A practical synthesis of nobiletin, a polymethoxylated citrus flavone, was accomplished by utilizing our novel flavone synthesis. Synthetic nobiletin was labelled by selective demethylation and rapid incorporation of 11C atom. Positron emission tomography images successfully visualized the brain distribution, which may provide therapeutic benefits in the treatment of Alzheimer's disease. The Royal Society of Chemistry.
- Asakawa, Tomohiro,Hiza, Aiki,Nakayama, Miho,Inai, Makoto,Oyama, Dai,Koide, Hiroyuki,Shimizu, Kosuke,Wakimoto, Toshiyuki,Harada, Norihiro,Tsukada, Hideo,Oku, Naoto,Kan, Toshiyuki
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supporting information; experimental part
p. 2868 - 2870
(2011/04/22)
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- COGNITIVE DISORDER-AMELIORATING AGENT
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A cognitive impairment ameliorant is provided that is useful for the prevention or treatment of cognitive impairment, and particularly Alzheimer's disease. The cognitive impairment ameliorant contains royal jelly as an active ingredient thereof.
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- Acid catalyzed stereoselective rearrangement and dimerization of flavenes: synthesis of dependensin
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Appropriately substituted flavenes undergo stereoselective rearrangement and dimerization when treated with methanolic hydrochloric acid to give benzopyranobenzopyrans. A rationale for the rearrangement is proposed. This synthetic methodology has been used for a high yield synthesis of the natural product dependensin.
- Deodhar, Mandar,Black, David StC,Kumar, Naresh
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p. 5227 - 5235
(2008/02/01)
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- Improved, rapid and efficient synthesis of polymethoxyflavones under microwave irradiation and their inhibitory effects on melanogenesis
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The microwave-assisted methylation of 2,5-dihydroxy-1,3-dimethoxybenzene with (CH3O)2SO2 for 5 min gave easily 1,2,3,5-tetramethoxybenzene, which was converted into pentamethoxybenzene. The microwave-assisted Friedel-Crafts acylation of pentamethoxybenzene in the presence of In(CF3SO3)3 gave pentamethoxyacetophenone for 15 min under solvent-free conditions in high yield. The microwave-assisted cyclization reaction of the diketones, which were synthesized from the acetophenone via three steps under microwave irradiation, gave the desired polymethoxyflavones for 1.5-3 min in high yields. The polymethoxyflavones showed inhibitory effects on melanogenesis in a human melanoma.
- Tsukayama, Masao,Kawamura, Yasuhiko,Ishizuka, Takaaki,Hayashi, Shinji,Torii, Fumihito
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p. 2775 - 2784
(2007/10/03)
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- 5-HYDROXY-7,8,2',4'-TETRAMETHOXYFLAVONE FROM LIMNOPHILA RUGOSA
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The petrol extract of the aerial parts and roots of limnophila rugosa yielded a new flavone, 5-hydroxy-7,8,2',4'-tetramethoxyflavone Key Word Indx - Limnophila rugosa; Scropulariaceae; 5-hydroxy-7,8,2',4'-tetramethoxyflavone.
- Mukherjee, K. S.,Chakraborty, C. K.,Chatterjee, T. P.
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p. 1778 - 1779
(2007/10/02)
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- Constituents of the Root Bark of Murraya paniculata Collected in Indonesia
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A mixture of fatty acid esters (Va) of murrangatin was obtained from the root bark of Murraya paniculata (Rutaceae) collected in Indonesia together with eleven known constituents of chemotaxonomical significance, and their structures were characterized on
- Imai, Fujio,Itoh, Kikuo,Kishibuchi, Noriko,Kinoshita, Takeshi,Sankawa, Ushio
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p. 119 - 123
(2007/10/02)
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- Oxidative Rearrangement of Quinochalcones. Part 2. A Facile Synthesis of Linderone
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Friedel-Crafts acylation of 1,2,3,5-tetramethoxybenzene in diethyl ether afforded besides the acetophenone (6a), an abnormal product shown to be 3-ethoxy-2-hydroxy-4,6-dimethoxy-acetophenone (6b).Methylpedicinin (1b), prepared from compoumd (6a), was foun
- Bennett, Graham J.,Lee, Hiok-Huang
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p. 633 - 638
(2007/10/02)
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- Syntheses of 5,6,7- and 5,7,8-Trioxygenated 3',4'-Dihydroxyflavones Having Alkoxy Groups and Their Inhibitory Activities against Arachidonate 5-Lipoxygenase
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Arachidonate 5-lipoxygenase plays a pivotal role in the biosynthesis of leukotrienes.Cirsiliol (3',4',5-trihydroxy-6,7-dimethoxyflavone), a selective inhibitor of the enzyme, was derivatized by introducing alkyl groups of various chain lengths at position
- Horie, Tokunaru,Tsukayama, Masao,Kourai, Hiroki,Yokoyama, Chieko,Furukawa, Masayuki,et al.
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p. 2256 - 2262
(2007/10/02)
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