Purine acyclic nucleosides. Unambiguous synthesis of acyclovir via A furazano[3,4-d]pyrimidine
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Kelley,Schaeffer
p. 271 - 273
(2007/10/02)
Methods and compositions for treating viral infections and guanine acyclic nucleosides
9-Hydroxyethoxymethyl (and related) derivatives of certain 6-, and 2,6-substituted purines have been discovered to have potent anti-viral activities. Novel compounds and their pharmaceutically acceptable salts, pharmaceutical formulation containing the compounds of this invention, and the treatment of viral infections with these formulations are all disclosed. 9-(2-hydroxyethoxymethyl) guanine and 2-amino-9-(2-hydroxyethoxymethyl)adenine are examples of especially active compounds of this invention.
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(2008/06/13)
2-Amido-9-(2-acyloxyethoxymethyl)hypoxanthines
Method of preparing 9-(2-hydroxyethoxymethyl)guanine which comprises preparing the compound STR1 wherein R and R1 are hydrogen, lower alkyl and phenyl and then hydrolyzing same. 9-(2-hydroxyethoxymethyl)guanine is useful as an antiviral.
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(2008/06/13)
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