- Aromatic Spiranes, XII: Syntheses of Spiroindane-2,2'-indane>, 2,2'-Spirobi(5,6,7,8-tetrahydrobenzoindane) and Their Derivatives
-
The title compounds 26 and 32 were prepared by systematic mono- and bisanellation of sixmembered rings to the positions 5,6 and 5',6', resp. of 2,2'-spirobiindane.SE acylation and subsequent transformations of the acylgroups afforded many derivatives with substituents in positions 4 and 4' of the parent compounds which were required for testing semiempirical values of chirality functions. 5,6,7,8-tetrahydrobenzindane (9) and several of its 4-substituted derivatives were prepared as models for the anellation and substitution reactions.Tentative preferred conformations of the 4-acylgroups could be deduced from 1H-nmr spectra. - (Keywords: 5,6,7,8-Tetrahydrobenzoindane and derivatives; Mono- and bisanellation; 2,2'-Spirobiindane; 1H-nmr and mass spectra)
- Neudeck, Horst,Schloegl, Karl,Tscheplak, Heinz
-
-
Read Online
- Derivatives of 4-hydroxybutanoic acid and of its higher homologue as ligands of γ(g)-hydroxybutyrate (ghb) receptors, pharmaceutical compositions containing same and pharmaceutical uses
-
The invention concerns the field of synthesis organic chemistry applied to the pharmaceutical field and concerns novel derivatives of 4-hydroxybutanoic acid and its higher homologue, 5-hydroxypentanoic acid, their crotonic homologues, pharmaceutical compo
- -
-
Page/Page column 5
(2010/02/11)
-
- Aralkyl-tetrahydro-pyridines, their preparation and pharmaceutical compositions containing same
-
The present invention relates to compounds of formula (I): in which X represents N or CH; R1 represents a hydrogen or halogen atom or a CF3 group; n is an integer from 1 to 5; A represents a partially saturated carbonaceous bi- or tr
- -
-
Page/Page column 6
(2010/02/10)
-
- Phosphonic acid compounds, their production and use
-
The present invention relates to a compound of the general formula (I): STR1 wherein ring A is a benzene ring that may be substituted; Y is a divalent group as a constituent member of ring B forming a 5- to 8-membered ring; Q1 is a group of the formula --X--P(O)(OR1)(OR2) wherein X is a bond or a divalent group; R1 and R2, identical or different, are hydrogen or a lower alkyl, or may be combined together to form a ring; Q2 is hydrogen, a hydrocarbon group that may be substituted or a heterocyclic group that may be substituted; and the group of the formula --CON(Q1)(Q2) is connected to the a- or b-position carbon atom, or a salt thereof, which is useful as prophylactic and therapeutic agents of various metabolic bone diseases such as osteoporosis.
- -
-
-