The direct conversion of carbamates to ureas using aluminum amides
The conversion of carbamates into ureas using aluminum amide complexes is reported. This reaction is a convenient method to prepare bi-, tri- and tetra-substituted ureas from carbamate-protected primary or secondary amines by reaction with primary or secondary amines in the presence of stoichometric quantities of trimethylaluminum. A reactivity trend of the various carbamates was observed and methyl and benzyl carbamates were reacted selectively in the presence of t-butyl carbamates.
Lee, Sang-Hyuep,Matsushita, Hana,Clapham, Bruce,Janda, Kim D.
p. 3439 - 3443
(2007/10/03)
Rapid Microscale Synthesis: Solution phase parallel synthesis of a library of piperazines and piperidines using a water soluble base
A library of 1086 piperazines and 835 piperidines was prepared via Rapid Microscale Synthesis (RMS) using the water soluble base 1,1,3,3- tetramethylguanidine to catalyze the reactions and to simplify purification.
Xie, Yun Feng,Whitten, Jeffrey P.,Chen, Tina Y.,Liu, Zhengyu,McCarthy, James R.
p. 4077 - 4084
(2007/10/03)
Cyclic esters of 3,4-dihydroxy-thiophene-1,1-dioxide compounds and 3,4-dihydroxy-cyclopentadienone compounds
Cyclic esters of 3,4-dihydroxy-thiophene-1,1-dioxide and of the corresponding cyclopentadienone compound, and their manufacture. The compounds can be used as "solid forms" of phosgene, thiophosgene or oxalyl chloride, or as acyl transfer agents.
-
(2008/06/13)
More Articles about upstream products of 75534-73-5