Polyfunctional pyridines from nitroacetamidine and β-diketones. A useful synthesis of substituted imidazo[4,5-b]pyridines and related compounds
Nitroacetamidine undergoes a useful cyclocondensation with β-diketones to produce substituted 2-amino-3-nitropyridines. Use of an acylpyruvate generates hitherto unreported 2-amino-3-nitropyridine-4-carboxylates. These may be converted easily to functionalized imidazo[4,5-b]pyridines and oxazolo[5,4-b]pyridines.
Batt,Houghton
p. 963 - 969
(2007/10/02)
ELECTRON SPIN RESONANCE STUDIES. PART 64. THE HYDROXYL RADICAL-INDUCED DECARBOXYLATION OF METHIONINE AND SOME RELATED COMPOUNDS
Spin-trapping e.s.r. experiments employing both MeNO2 (in conjunction with generation of .OH from the TiIII-H2O2 couple in a flow system) and ButNO ( in conjunction with the photolytic decomposition of H2O2) confirm that the reaction of .OH with methionine, S-methylcysteine, and some related compounds effects oxidative decarboxylation.It is proposed that the reaction proceeds via the sequential formation of an hydroxyl adduct at sulphur, a sulphur-centred radical-cation, and a (cyclic) sulphuranyl radical in which the carboxylate function becomes bonded to sulphur.
Davies, Michael J.,Gilbert, Bruce C.,Norman, Richard O.
p. 731 - 738
(2007/10/02)
More Articles about upstream products of 7570-26-5