- Organometallic ligands for the localization and quantification of amyloid in vivo and in vitro
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Novel organometallic compounds for binding amyloid are described. Methods using such compounds for determining by imaging the localization or quantification of amyloid fibrils in a mammal, for diagnosing the degree of progression of Alzheimer's disease in a mammal, for monitoring the response to a therapy in a mammal having Alzheimer's disease, for identifying an agent useful for treating Alzheimer's disease, for treating Alzheimer's disease, and for detecting the presence of the infectious form of the prion protein, are also described.
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- Nucleophilic substitution in dibenz[b,d]iodolium and 11,12-dihydro-10H-dibenz[b,g]iodocinium cations
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Treatment of dibenz[b,d]iodolium tetrafluoroborate with NO2-, Br-, and N3- ions gave, along with nucleophilic substitution products, 2-nitro-, 2-bromo-, and 2-azido-2′-iodiphenyls, diphenyl, 2-iododiphenyl, and 2,2′-diiododiphenyl (products of one electron reduction), whereas 11,12-dihydro-10H-dibenz[b,g]-iododnium tetrafluoroborate underwent nucleophilic substitution with all three nucleophiles to give a single product in each case: 1-(2-nitrophenyl)-, 1-(2-bromophenyl)-, or 1-(2-azidophenyl)-3-(2-iodophenyl)propane. 1998 Plenum Publishing Corporation.
- Vanchikov,Bobyleva,Komissarova,Kulikov,Tolstaya
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p. 371 - 377
(2007/10/03)
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