- A convergent strategy towards febrifugine and related compounds
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We report a modular five step synthetic route to the febrifugines that employs 2-(chloromethyl)allyl-trimethylsilane as a conjunctive reagent for the coupling of the piperidine and quinazolinone groups. We also demonstrate the application of a recent Rh-catalyzed quinazolinone synthesis for the facile generation of febrifugine analogs.
- Maiden,Mbelesi,Procopiou,Swanson,Harrity
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p. 4159 - 4169
(2018/06/12)
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- Regioselective synthesis of benzimidazolones via cascade C-N coupling of monosubstituted ureas
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A direct method for the regioselective construction of benzimidazolones is reported wherein a single palladium catalyst is employed to couple monosubstituted urea substrates with differentially substituted 1,2-dihaloaromatic systems. In this method, the catalyst is able to promote a cascade of two discrete chemoselective C-N bond-forming processes that allows the highly selective and predictable formation of complex heterocycles from simple, readily available starting materials.
- Ernst, Johannes B.,Tay, Nicholas E. S.,Jui, Nathan T.,Buchwald, Stephen L.
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supporting information
p. 3844 - 3846
(2014/08/05)
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- INDAZOLE DERIVATIVES THAT INHIBIT TRPV1 AND USES THEREOF
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Compounds of formula (I) wherein R3, R7, R9 and L are defined in the description are TRPV1 antagonists that exhibit low inhibitory activity against CYP3A4. Compositions comprising such compounds and methods for treating co
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Page/Page column 34
(2008/06/13)
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- Oxime derivatives for the treatment of dyslipidemia and hypercholesteremia
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The present invention relates to compounds of Formula (I) which may be useful in the treatment of diseases, such as, metabolic disorders, dyslipidemia and/or hyperchloesterolemia: 1
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- Heterocyclic derivatives for the treatment of diabetes and other diseases
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The present invention relates to certain substituted heterocycles of Formula (I) which are useful in the treatment of diseases related to lipid and carbohydrate metabolism, such as type 2 diabetes, adipocyte differentiation, uncontrolled proliferation, such as lymphoma, Hodgkin's Disease, leukemia, breast cancer, prostate cancer or cancers in general; and inflammation, such as osteoarthritis, rheumatoid arthritis, Crohn's Disease or Inflammatory Bowel Disease.
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- Use of Potassium Bromate: Bromination of Halobenzenes and Halobenzoic Acids
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Syntheses of bromo compounds by the bromination of halobenzenes and halobenzoic acids using potassium bromate under acidic condition have been discussed.
- Banerjee, Amalendu,Banerjee, Gopal Chandra,Dutt, Sachchidananda,Banerjee, Santa (Mrs.),Samaddar, Haraprasad
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p. 640 - 642
(2007/10/02)
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