- Preparation method for high-purity 3-(2,2,2-trimethylhydrazine)methyl propionate crude drug intermediate
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The invention discloses a preparation method for a high-purity 3-(2,2,2-trimethylhydrazine)methyl propionate crude drug intermediate. The intermediate is an important medical intermediate of mildronate and aziridine anti-cancer drugs. A conventional method is that 1,1-dimethylhydrazine reacts with methyl acrylate, and vacuum distillation is performed and a methylation reaction is performed to obtain a target product. The intermediate obtained by this type of the reaction contains ammonium salt related impurities so that the variety and content of final crude drug impurities exceed an impuritylimited field of European Pharmacopoeia, and a purifying technology is complicated. The invention provides an efficient improved method for preparing the two types of the compounds. A high-purity product can be obtained and a productive rate of the product is improved, cost is reduced, and industrial large-scale production is realized.
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Paragraph 0012; 0014; 0018-0019
(2019/03/08)
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