- Metal-free sp3 C-H bond oxidation and functionalization of α-bromoketones to quinoxalinone, benzoxazinone, and benzothiazinone heterocyclic compounds
-
A series of heterocyclic compounds (benzothiazinones, benzoxazinones and quinoxalinones) were efficiently synthesized in excellent yields via α-bromoketones with o-substituted aniline (2-aminothiophenol, aryl-1,2-diamines and 2-aminophenol). This protocol accomplishes sp3 C-H bond oxidation and functionalization in one-pot without any metal catalyst.
- Chen, Xiuling,Guo, Fang,Qi, Hongxue,Tian, Haiying,Wei, Tianlong
-
p. 1138 - 1148
(2021/06/21)
-
- Catalyst free synthesis of 2-Aryl-2H-benzo[b][1,4]oxazines and 3-Aryl-2H-benzo[b][1,4]thiazin-2-ones: An ultrasonication-assisted strategy
-
An ultrasonication-assisted synthesis of 2-Aryl-2H-benzo[b][1,4]oxazines and 3-aryl-2H-benzo[b][1,4]thiazin-2-ones has been established by reacting phenacyl bromides with 2-aminophenol and 2-aminothiophenol, respectively. This approach fosters flexibility in generating a diverse range of 1,4-benzoxazines and 1,4-benzothiazinones under catalyst-free reaction conditions. Further scope toward the synthesis of rarely occurring bis-benzoxazine adduct has also been explored, which enabled us to propose the reaction mechanism.
- Teli, Bisma,Waseem, Malik Abdul,Rashid, Showkat,Ganaie, Bilal Ahmad,Bhat, Bilal A.
-
supporting information
p. 1541 - 1545
(2021/04/21)
-
- [Ir(P-OP)]-catalyzed asymmetric hydrogenation of diversely substituted C=N-containing heterocycles
-
Iridium(I) complexes of enantiomerically pure phosphine-phosphite ligands ([Ir(Cl)(cod)(P - OP)]) efficiently catalyze the enantioselective hydrogenation of diverse C=N-containing heterocyclic compounds (benzoxazines, benzoxazinones, benzothiazinones, and quinoxalinones; 25 examples, up to 99% ee). A substrate-to-catalyst ratio as high as 2000:1 was reached.
- Nunez-Rico, Jose Luis,Vidal-Ferran, Anton
-
p. 2066 - 2069
(2013/06/04)
-
- From phenothiazine to 3-phenyl-1,4-benzothiazine derivatives as inhibitors of the Staphylococcus aureus NorA multidrug efflux pump
-
Overexpression of efflux pumps is an important mechanism by which bacteria evade effects of substrate antimicrobial agents and inhibition of such pumps is a promising strategy to circumvent this resistance mechanism. NorA is a Staphylococcus aureus multid
- Sabatini, Stefano,Kaatz, Glenn W.,Rossolini, Gian Maria,Brandini, David,Fravolini, Arnaldo
-
experimental part
p. 4321 - 4330
(2009/05/07)
-
- New dyes based on 3-aryl-benzo- and -naphtho-1,4-thiazines
-
3-Aryl-2H-1,4-benzothiazines have been converted into cyanine dyes by condensing their hydroperchlorates with aldehydes, and into azo-compounds by coupling with reactive diazonium salts. The azo-compounds were also obtained by condensing arylglyoxal hydra
- MacKenzie, Neil E.,Thomson, Ronald H.,Greenhalgh, Colin W.
-
p. 2923 - 2932
(2007/10/02)
-