- 3'-Fluoro-5'-hydroxythalidomide and derivatives thereof
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There are provided a novel 3′-fluoro-5′-hydroxythalidomide derivative and an optically active substance thereof A 3′-fluoro-5′-hydroxythalidomide derivative represented by the general formula [A]: wherein R1, R2 and R3 are each a hydrogen atom; and X is C═O, and an optically active substance thereof. As analogs of thalidomide, the 3′-fluoro-5′-hydroxythalidomide derivatives are useful in the treatment of erythema nodosum of Hansen's disease, prurigo, rheumatism, Crohn's disease, graft-versus-host disease, Behcet's disease, myeloma, aphtha ulcer and the like. Further, the 3′-fluoro-5′-hydroxythalidomide derivative is useful as a drug used for treatment of multiple myeloma, TNF-α related diseases and the like.
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Page/Page column 4
(2009/07/17)
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- On the reaction of 4-substituted trimethyltin aromatics with perchlorylfluoride
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To evaluate the suitability of [18F]perchorylfluoride [18F]FClO3 as an electrophilic fluorination agent for the preparation of radiopharmaceuticals, the reactivity non-radioactive FClO3 towards 4-substituted trimethyltin aromatic compounds was studied. Contrary to the expectation, an electrophilic fluorination of the aromatic nucleus did not occur. The reaction of perchlorylfluoride with aromatic trimethylstannyl compounds resulted in the formation of trimethyltin fluoride and the respective destannylated aromatics in variable yields.
- Hiller, Achim,Patt, J?rg T.,Steinbach, J?rg
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p. 3737 - 3742
(2007/10/03)
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