Aqueous phosphoric acid as a mild reagent for deprotection of the t-butoxycarbonyl group
Aqueous phosphoric acid (85 wt%) is an efficient and mild reagent for the deprotection of N-BOC groups. Acid sensitive functionalities including benzyl and methyl esters, TBDMS ether, CBZ and isopropylidene groups are compatible with the reaction conditions. The reactions are high yielding, and the workup is convenient.
Li, Bryan,Bemish, Raymond,Buzon, Richard A.,Chiu, Charles K.-F.,Colgan, Stephen T.,Kissel, William,Le, Tung,Leeman, Kyle R.,Newell, Lisa,Roth, Joshua
p. 8113 - 8115
(2007/10/03)
More Articles about upstream products of 76387-79-6