- Total syntheses and in vivo quantitation of novel neurofuran and dihomo-isofuran derived from docosahexaenoic acid and adrenic acid
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Neurofurans (NeuroFs) and dihomo-isofurans (dihomo-IsoFs) are produced in vivo by non-enzymatic free-radical pathways from docosahexaenoic and adrenic acids, respectively. As these metabolites are produced in minute amounts, their analyses in biological samples remain challenging. Syntheses of neurofuran and dihomo-isofurans described are based on a pivotal strategy, thanks to an enantiomerically enriched intermediate, which allowed, for the first time, access to both families: the alkenyl and enediol. Owing to this formation, quantitation of specific NeuroF and dihomo-IsoFs in biological samples was attainable.
- De La Torre, Aurlien,Lee, Yiu Yiu,Mazzoni, Attilio,Guy, Alexandre,Bultel-Ponc, Valrie,Durand, Thierry,Oger, Camille,Lee, Jetty Chung-Yung,Galano, Jean-Marie
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supporting information
p. 2442 - 2446
(2015/01/30)
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