Carbon disulfide promoted reactions of 2-chloro-4,5-dihydro-imidazole with some n-nucleophiles
The reactions of 2-chloro-4,5-dihydroimidazole 1 with o-substituted anilines and azoles promoted by carbon disulfide have been carried out. Ab initio MO calculations were used to elucidate the mechanism of the reaction of 1 with N-nucleophilic reagents. A facile synthesis of 2-(4,5-dihydroimidazol-2-yl)-1H-indazole 3e bearing structural resemblances to 2-BFI, a potent and selective agonist of imidazoline I2 receptors, is also described. Structure of 3e was confirmed by NMR spectroscopy and X-ray analysis.
Saczewski,Saczewski,Gdaniec
p. 1203 - 1206
(2007/10/03)
New 2-aryliminoimidazolidines. I. Synthesis and antihypertensive properties of 2-(2-phenoxyphenylimino)imidazolidines and related compounds
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Matsuo,Taniguchi,Katsura,Kamitani,Ueda
p. 4409 - 4421
(2007/10/02)
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