REACTION BETWEEN 1-ARENESULPHONYL-3-NITRO-1,2,4-TRIAZOLES AND NUCLEOSIDE BASE RESIDUES. ELUCIDATION OF THE NATURE OF SIDE-REACTIONS DURING OLIGONUCLEOTIDE SYNTHESIS.
The protected guanosine and uridine derivatives (3a, 3b, and 4) react with 1-(mesitylene-2-sulphonyl)-3-nitro-1,2,4-triazole (MSNT, 2a) to give 5a, 5b and 7, respectively; 9 is converted into 10 in the same way.The reactions proceed more rapidly in the presence of diphenyl phosphate.
Get Best Price for76887-35-9Acetic acid (2R,3R,4R,5R)-4-acetoxy-5-acetoxymethyl-2-[2-benzoylamino-6-(3-nitro-[1,2,4]triazol-1-yl)-purin-9-yl]-tetrahydro-furan-3-yl ester